Temporal population structure, a genetic dating method for ancient Eurasian genomes from the past 10,000 years.
Temporal population structure, a genetic dating method for ancient Eurasian genomes from the past 10,000 years.
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DOI：
10.1016/j.crmeth.2022.100270
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发表时间：
2022-08-22
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影响因子：
--
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放射性碳测年是考古学中估计骨骼年龄的黄金标准，是研究骨骼起源的关键。许多已发表的古代基因组缺乏可靠和直接的日期，这导致了模糊和矛盾的报告。我们开发了时间人口结构（TPS），这是一种基于DNA的基因组年代测定方法，从中石器时代晚期到今天，并将其应用于3，591名古代和1，307名现代欧亚人。TPS预测与已知日期一致，并正确地解释了亲属关系。如一个测试案例所示，对日期不佳的欧亚样本进行TPS测年解决了文献中相互矛盾的报告。我们还证明了TPS如何随着时间的推移提高研究表型性状的能力。当放射性碳测年不可行或不确定时，TPS可以用于为小于10，000年前的样本开发替代假设，随着时间的推移，随着古代数据的积累，这一限制可能会得到解决。大约50%的古代基因组缺乏可靠的日期，这导致人们对基因组数据的理解不佳TPS是一种基于人工智能的基因组测年工具，可以将DNA数据转换为日期（<10，000 BP）TPS可以用于确定古代基因组的日期并解决日期争议准确的日期对于解释古基因组数据至关重要。考古学的黄金标准方法是放射性碳测年法。然而，放射性碳定年的一个主要限制是在这个过程中涉及大量的胶原蛋白提取。因此，几乎一半的已发表的古代基因组缺乏可靠和直接的日期，这导致了模糊和矛盾的报告。在这里，我们提出了时间人口结构（TPS），这是一种基于机器学习的基因组测年方法，适用于从中石器时代晚期到现代的基因组。准确的年代测定对于解释古基因组数据至关重要，但近一半的古代基因组缺乏可靠的年代，这导致了模糊和相互矛盾的报告。为了克服这些问题，Behnamian et al.开发TPS，一种用于基因组（<10，000 BP）的基因组测年工具，并在15，000个基因组上证明其准确性。
Radiocarbon dating is the gold standard in archeology to estimate the age of skeletons, a key to studying their origins. Many published ancient genomes lack reliable and direct dates, which results in obscure and contradictory reports. We developed the temporal population structure (TPS), a DNA-based dating method for genomes ranging from the Late Mesolithic to today, and applied it to 3,591 ancient and 1,307 modern Eurasians. TPS predictions aligned with the known dates and correctly accounted for kin relationships. TPS dating of poorly dated Eurasian samples resolved conflicting reports in the literature, as illustrated by one test case. We also demonstrated how TPS improved the ability to study phenotypic traits over time. TPS can be used when radiocarbon dating is unfeasible or uncertain or to develop alternative hypotheses for samples younger than 10,000 years ago, a limitation that may be resolved over time as ancient data accumulate. ∼50% of ancient genomes lack reliable dates, which leads to poor understanding Genomic data contain markers indicative of the age of the sample TPS is an AI-based genomic dating tool that converts DNA data to dates (<10,000 BP) TPS can be used to date ancient genomes and resolve dating disputes Accurate dating is essential to the interpretation of paleogenomic data. The gold standard method in archeology is radiocarbon dating. However, a major limitation of radiocarbon dating is the high amount of collagen extraction involved in the process. Consequently, almost half of all published ancient genomes lack reliable and direct dates, which results in obscure and contradictory reports. Here, we present the temporal population structure (TPS), a machine learning-based genomic dating method for genomes ranging from the fringes of the Late Mesolithic to modern times. Accurate dating is essential to the interpretation of paleogenomic data, yet nearly half of all ancient genomes lack reliable dates, which results in obscure and contradictory reports. To overcome these problems, Behnamian et al. develop TPS, a genomic dating tool for genomes (<10,000 BP), and demonstrate its accuracy on ∼5,000 genomes.
影响因子：
3.5
作者：
Amos W
通讯作者：
Amos W