Leukocyte interactions with vascular endothelium. New insights into selectin-mediated attachment and rolling.
Leukocyte interactions with vascular endothelium. New insights into selectin-mediated attachment and rolling.
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DOI：
10.4049/jimmunol.155.2.525
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发表时间：
1995-07
影响因子：
4.4
通讯作者：
K. Ley;T. Tedder
中科院分区：
文献类型：
--
作者：
K. Ley;T. Tedder
炎症的最早迹象之一是白细胞从血流中被捕获，随后它们沿着毛细血管后小静脉的内皮滚动。这篇评论总结了最近对白细胞滚动的分子基础的认识，这些分子基础是从基因靶向小鼠、抗体阻断研究以及体外和体内重建试验中获得的。这些数据揭示了选择素如何单独和共同地促进白细胞捕获和随后在血管内皮上滚动的过程。
Among the earliest signs of inflammation is the capture of leukocytes from the blood stream and their subsequent rolling along the endothelium of postcapillary venules. This commentary summarizes recent insight into the molecular basis of leukocyte rolling gained from gene-targeted mice, Ab blocking studies, and in vitro and in vivo reconstitution assays. These data reveal how the selectins individually and collectively contribute to the process of leukocyte capture and subsequent rolling on vascular endothelium.