The implication of tumor biomarker CA19-9 in the diagnosis of intracranial epidermoid cyst.
The implication of tumor biomarker CA19-9 in the diagnosis of intracranial epidermoid cyst.
复制标题
肿瘤标志物CA19-9在颅内表皮样囊肿诊断中的意义
DOI：
10.18632/oncotarget.12934
复制
发表时间：
2017-01-10
期刊：
影响因子：
--
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Wang Y;Yan W;Wu Q;Chen G;Zhang J
目的颅内表皮样囊肿（IEC）的诊断主要依靠MRI，费时费力。肿瘤生物标志物在IEC中的应用尚未得到系统研究。在这里，我们筛选了一组常用的肿瘤生物标志物，以评估其在IEC中的诊断价值。结果检测42例IEC患者和42例健康对照者血清肿瘤标志物。仅血清CA 19 -9水平在IEC组中显著较高（中值20.3U/ml对6.5U/ml，p < 0.001）。CA 19 -9的曲线下面积为0.806（95%CI 0.700-0.912），临界值为13.15 U/ml（灵敏度71.4%，特异性97.6%）。CA 19 -9阳性组和CA 19 -9阴性组之间的肿瘤大小存在显著差异（64.14 ± 67.91 cm 3 vs. 19.43 ± 13.76 cm 3，p = 0.04），线性回归分析显示正相关。两组的切除范围和复发率均无显著差异。方法回顾性研究2009年至2014年期间接受治疗的IEC患者。我们分析了IEC和健康对照组中常见的血清肿瘤生物标志物，包括糖链抗原19-9（CA 19 -9）、癌胚抗原、糖链抗原125和鳞状细胞癌的表达。建立受试者工作特征曲线以评价诊断准确性。结论血清CA 19 -9水平高于13.15U/ml时，在排除胃肠道肿瘤、肺癌、炎症等相关疾病的可能性后，应考虑IEC的存在。CA 19 - 9在术后评估和监测中的价值有待进一步的前瞻性研究。
Object The diagnosis of intracranial epidermoid cyst (IEC) relies solely on MRI, which is time and money consuming. The application of tumor biomarkers in IEC has never been systematically studied. Here we screened a group of commonly used tumor biomarkers to assess their diagnostic value in IEC. Results Serum tumor biomarkers were assessed in 42 IECs and 42 paired healthy controls. Only serum CA19-9 level was significantly higher in the IEC group (median 20.3U/ml vs. 6.5U/ml, p < 0.001). Area under curve for CA19-9 was 0.806 (95% CI 0.700–0.912), with cutoff value of 13.15 U/ml (sensitivity 71.4%, specificity 97.6%). Tumor size was significantly different between CA19-9 positive and CA19-9 negative groups(64.14 ± 67.91cm3 vs. 19.43 ± 13.76 cm3, p = 0.04) and linear regression analysis revealed a positive correlation. Neither the extent of resection nor recurrence rate showed any significant difference between the two groups. Methods This is a retrospective study of IEC patients treated between 2009 and 2014. We analyzed the expression of common serum tumor biomarkers, including carbohydrate antigen 19–9 (CA19-9), carcinoembryonic antigen, carbohydrate antigen125 and squamous cell carcinoma in both IEC and healthy control group. Receiver operating characterisitics curves were constructed to evaluate the diagnostic accuracy. Conclusions Our data indicated that for serum CA19-9 level higher than 13.15U/ml, after excluding the possibility of gastrointestinal system tumor, lung cancer, inflammation and other related diseases, the existence of IEC should be considered. Further prospective study is needed to gain more understanding of the value of CA19- 9 in postoperative evaluation and surveillance.