Frontal cortex atrophy predicts cognitive impairment in multiple sclerosis
Frontal cortex atrophy predicts cognitive impairment in multiple sclerosis
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DOI：
10.1176/appi.neuropsych.14.1.44
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发表时间：
2002-12-01
影响因子：
2.9
通讯作者：
Munschauer, F
中科院分区：
文献类型：
--
作者：
Benedict, RHB;Bakshi, R;Munschauer, F
在 355 名多发性硬化症 (MS) 患者中研究了皮质萎缩的区域测量与神经心理 (NP) 功能障碍之间的关联。患者接受神经系统检查、MRI 和 NP 测试。盲定量 MRI 分析得出总 T-2 病变面积 (TLA) 和第三脑室宽度 (3VW)。通过盲视检查评定的皮质萎缩在上额叶和顶叶皮质中比其他区域更广泛，没有 MRI 测量与抑郁评分相关。 TLA 和 3VW 与每个 NP 测试显着相关。双侧上额叶皮层的皮质萎缩测量被保留在预测言语学习、空间学习、注意力和概念推理障碍的回归模型中。作者得出结论，脑萎缩可预测 NP 损伤，同时考虑到 TLA 或 3VW 的影响。多发性硬化症中最容易出现萎缩和认知变化的皮质区域是右额叶和左上额叶。
The association between regional measures of cortical atrophy and neuropsychological (NP) dysfunction was studied in 355 multiple sclerosis (MS) patients. Patients underwent neurological examination, MRI, and NP testing. Blind quantitative MRI analysis yielded total T-2 lesion area (TLA) and third ventricle width (3VW). Cortical atrophy, rated by blind visual inspection, was more extensive in superior frontal arid parietal cortices than in other regions, No MRI measures were correlated with depression scores. TLA and 3VW were significantly correlated with each NP test. Cortical atrophy measures for bilateral superior frontal cortex were retained in regression models predicting impairments in verbal learning, spatial learning, attention, and conceptual reasoning. The authors conclude that cerebral atrophy predicts NP impairment while accounting for the influence of TLA or 3VW. Regions of cortex most susceptible to atrophic and cognitive changes in MS are the right and left superior frontal lobes.