Anisomycin and Related Antibiotics
Anisomycin and Related Antibiotics
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DOI：
10.1007/978-3-642-46407-2_1
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
A. Jimenez;D. Vazquez
中科院分区：
文献类型：
--
作者：
A. Jimenez;D. Vazquez
抗生素茴香霉素首先由Sobin和Tanner（1954）从两种不同的链霉菌的培养物中分离出来，随后被鉴定为S。griseolusandS. roseochromogenes（坦纳等，1955），最近该药物也从链霉菌中分离出来。638号 图1A-C.茴香霉素和一些结构相关化合物的化学结构（Ishida et al.，1974）。结晶茴香霉素可溶于水，并且水溶液在微酸性pH（pH 4至6）下似乎比在碱性pH下更稳定（Tanneret等人，1955;BarbacidandVázquez，1973）. Beereboom et al.（1965）和Butler（1968）（图1）确定了该药物的化学结构和立体化学构型，并完成了其完整的化学合成（Oida和Ohki，1969; Felner和Schenker，1970）。
The antibiotic anisomycin was first isolated bySobinandTanner(1954) from culture filtrates of two different species ofStreptomyces, subsequently identified asS. griseolusandS. roseochromogenes(Tanner et al, 1955), and more recently the drug has also been isolated fromStreptomycessp. No. 638 Fig. 1A-C.Chemical structure of anisomycin and some structurally related compoundsbyIshidaet al. (1974). Crystalline anisomycin is soluble in water, and aqueous solutions appear to be more stable at slightly acidic pH (pH 4 to 6) than at alkaline pH (Tanneret al., 1955;BarbacidandVázquez, 1973). Both the chemical structure and the stereochemical configuration of the drug were established byBeereboomet al. (1965) andButler(1968) (Fig. 1), and its complete chemical synthesis has also been achieved (OidaandOhki, 1969;FelnerandSchenker, 1970).