Dosage effects for superoxide dismutase-1 in nucleated cells aneuploid for chromosome 21.
Dosage effects for superoxide dismutase-1 in nucleated cells aneuploid for chromosome 21.
复制标题
超氧化物歧化酶-1 对 21 号染色体非整倍体有核细胞的剂量影响。
DOI：
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发表时间：
1977
影响因子：
9.8
通讯作者：
'. CHARLESJ.EPSTEIN
中科院分区：
文献类型：
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作者：
William W. Feaster;Lillian W. Kwok;'. CHARLESJ.EPSTEIN
21三体患者淋巴细胞和多形核粒细胞中21号染色体超氧化物歧化酶-1 （SOD-1）活性测定结果显示，21三体患者细胞中SOD-1活性分别增加38%和40%。同样，三体成纤维细胞中的SOD-1活性增加了81%，而21号染色体的单体细胞只有正常活性的60%。结合三体红细胞和血小板中SOD-1活性的数据，本研究结果有力地证实了该酶在21号染色体非整倍体细胞中存在真正的剂量效应。然而，对三体成纤维细胞中谷胱甘肽过氧化物酶活性的测定结果并没有证实先前报道的21号染色体相关剂量效应的可能性。
Assays of the activity of chromosome 21 determined superoxide dismutase-1 (SOD-1) in lymphocytes and polymorphonuclear granulocytes have demonstrated 38% and 40% increases, respectively, in cells from individuals with trisomy 21. Similarly, SOD-1 activity in trisomic fibroblasts is increased by 81%, while cells monosomic for chromosome 21 have only 60% of normal activity. Taken together with the data on SOD-1 activities in trisomic erythrocytes and platelets, the present results firmly confirm the existence of a true dosage effect for this enzyme in cells aneuploid for chromosome 21. However, the results of assays of the activity of glutathione peroxidase in trisomic fibroblasts did not confirm the possibility previously reported of a chromosome 21 related dosage effect for this enzyme.