Cytotoxic Polyketides from a Marine-derived Fungus Aspergillus glaucus
Cytotoxic Polyketides from a Marine-derived Fungus Aspergillus glaucus
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来自海洋源性真菌灰白曲霉的细胞毒性聚酮化合物
DOI：
10.1021/np800303t
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发表时间：
2008-11-01
影响因子：
5.1
通讯作者：
Gu, Qianqun
中科院分区：
文献类型：
--
作者：
Du, Lin;Zhu, Tianjiao;Gu, Qianqun
从海洋源真菌青丝曲霉中分离得到8个新的芳香聚酮（2、4-6、8、14、16和17）和8个已知的类似物（3、7、9-13和15）。用光谱学和化学方法鉴定了新化合物的结构和立体化学性质，并对其对HL-60和A-549细胞株的细胞毒性进行了评价。
Eight new aromatic polyketides (2, 4-6, 8, 14, 16, and 17) together with eight known analogues (3, 7, 9-13, and 15) were isolated from the marine-derived fungus Aspergillus glaucus. The structures and stereochemistry of the new compounds were elucidated by spectroscopic and chemical methods, and their cytotoxicities were evaluated against the HL-60 and A-549 cell lines.