Fluid Retention and Rostral Fluid Shift in Sleep-Disordered Breathing
Fluid Retention and Rostral Fluid Shift in Sleep-Disordered Breathing
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DOI：
10.2174/1573402112666160114093550
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发表时间：
2016-01-01
影响因子：
2.3
通讯作者：
Kasai, Takatoshi
中科院分区：
文献类型：
--
作者：
Kasai, Takatoshi
睡眠呼吸障碍（SDB）很常见，对心血管疾病的发病率和死亡率有不利影响。尽管SDB的发病机制是多因素的，但SDB在液体潴留疾病（如耐药高血压、终末期肾病和心力衰竭）患者中普遍存在，提示液体潴留可能在SDB的发病机制中发挥作用。白天，液体很可能积聚在腿部，晚上躺下时，液体就会从腿部排出。许多数据表明，一些从腿部排出的液体可能会重新分配到上半身，从而易患SDB。这篇综述文章将强调SDB与液体潴留或吻侧液体移位之间关系的证据，并讨论它们之间的联系机制。
Sleep-disordered breathing (SDB) is common and adversely affects cardiovascular morbidity and mortality. Despite multifactorial pathogenesis, SDB is prevalent in patients with fluid retention disorders, such as drug-resistant hypertension, end-stage renal disease, and heart failure, suggesting that fluid retention may play a role in the pathogenesis of SDB. During the day, fluid is likely to accumulate in the legs, and upon lying down at night is displaced from the legs. Many data suggest that some of this fluid displaced from the legs may redistribute to the upper body and predispose to SDB. This review article will highlight evidence for a relationship between SDB and fluid retention or rostral fluid shift, and discuss mechanisms that link them.