Novel tools to unravel molecular mechanisms in cilia-related disorders
Novel tools to unravel molecular mechanisms in cilia-related disorders
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DOI：
10.1016/j.tig.2006.03.002
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发表时间：
2006-05-01
影响因子：
11.4
通讯作者：
Omran, Heymut
中科院分区：
文献类型：
--
作者：
Fliegauf, Manfred;Omran, Heymut
纤毛是从细胞表面延伸的毛发状细胞器，执行运动（例如呼吸纤毛）和/或感觉功能（例如肾性单眼）。纤毛和鞭毛的基本超微结构已被电子显微镜很好地建立。最近的几份报告提供了有趣的新见解复杂的分子组成的纤毛和鞭毛。这些来自基因组、蛋白质组和转录组分析的数据将有助于系统地发现和理解与人类纤毛相关的疾病，如原发性纤毛运动障碍、多囊肾病和男性不育症相关的基因。
Cilia are hair-like organelles extending from the cell surface that execute motile (e.g. respiratory cilia) and/or sensory functions (e.g. renal monocilia). The basic ultrastructure of cilia and flagella has been well established by electron microscopy. Several recent reports have now provided intriguing new insights into the complex molecular composition of cilia and flagella. These data from genome, proteome and transcriptome analyses will facilitate the systematic discovery and understanding of genes responsible for human cilia-related diseases, such as primary ciliary dyskinesia, polycystic kidney disease and male sterility.