Mesenchymal Stem Cells-Derived Exosomes as Dexamethasone Delivery Vehicles for Autoimmune Hepatitis Therapy.
Mesenchymal Stem Cells-Derived Exosomes as Dexamethasone Delivery Vehicles for Autoimmune Hepatitis Therapy.
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间充质干细胞衍生的外泌体作为地塞米松递送载体用于自身免疫性肝炎治疗
DOI：
10.3389/fbioe.2021.650376
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发表时间：
2021
影响因子：
5.7
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Zhao J;Li Y;Jia R;Wang J;Shi M;Wang Y
外泌体（Exosomes，Exos）是一种纳米囊泡（约100 nm），具有良好的生物相容性和低免疫原性，是一种很有前途的药物载体。先前的研究表明，间充质干细胞（MSC）分泌的Exos对刀豆球蛋白A（Con A）诱导的肝损伤提供保护。在本研究中，确认了Exos的保护作用，并制备了名为Exo@DEX的掺入地塞米松（DEX）的Exos。然后研究在Con A诱导的自身免疫性肝炎（AIH）小鼠模型中，与游离药物和未处理的Exos相比，ExoODEX是否可以更有效地发挥作用。结果表明，Exo@DEX有效地改善了AIH中DEX在肝脏中的积累。这些数据表明，Exo@DEX是一种有前途的AIH药物载体，并可能在其他疾病中应用。
Exosomes (Exos) are nanosized vesicles (around 100 nm) that recently serve as a promising drug carrier with high biocompatibility and low immunogenicity. Previous studies showed that Exos secreted from mesenchymal stem cells (MSCs) provide protection for concanavalin A (Con A)-induced liver injury. In this study, the protective effect of Exos is confirmed, and dexamethasone (DEX)-incorporated Exos named Exo@DEX are prepared. It is then investigated whether Exo@DEX can function more efficiently compared to free drugs and naive Exos in a Con A-induced autoimmune hepatitis (AIH) mouse model. The results show that Exo@DEX efficiently improves the accumulation of DEX in AIH in the liver. These data suggest that Exo@DEX is a promising drug carrier for AIH and could have applications in other diseases.