Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015.
Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015.
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DOI：
10.1016/j.jacc.2017.04.052
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发表时间：
2017-07-04
影响因子：
24
通讯作者：
Murray C
中科院分区：
文献类型：
--
作者：
Roth GA;Johnson C;Abajobir A;Abd-Allah F;Abera SF;Abyu G;Ahmed M;Aksut B;Alam T;Alam K;Alla F;Alvis-Guzman N;Amrock S;Ansari H;Ärnlöv J;Asayesh H;Atey TM;Avila-Burgos L;Awasthi A;Banerjee A;Barac A;Bärnighausen T;Barregard L;Bedi N;Belay Ketema E;Bennett D;Berhe G;Bhutta Z;Bitew S;Carapetis J;Carrero JJ;Malta DC;Castañeda-Orjuela CA;Castillo-Rivas J;Catalá-López F;Choi JY;Christensen H;Cirillo M;Cooper L Jr;Criqui M;Cundiff D;Damasceno A;Dandona L;Dandona R;Davletov K;Dharmaratne S;Dorairaj P;Dubey M;Ehrenkranz R;El Sayed Zaki M;Faraon EJA;Esteghamati A;Farid T;Farvid M;Feigin V;Ding EL;Fowkes G;Gebrehiwot T;Gillum R;Gold A;Gona P;Gupta R;Habtewold TD;Hafezi-Nejad N;Hailu T;Hailu GB;Hankey G;Hassen HY;Abate KH;Havmoeller R;Hay SI;Horino M;Hotez PJ;Jacobsen K;James S;Javanbakht M;Jeemon P;John D;Jonas J;Kalkonde Y;Karimkhani C;Kasaeian A;Khader Y;Khan A;Khang YH;Khera S;Khoja AT;Khubchandani J;Kim D;Kolte D;Kosen S;Krohn KJ;Kumar GA;Kwan GF;Lal DK;Larsson A;Linn S;Lopez A;Lotufo PA;El Razek HMA;Malekzadeh R;Mazidi M;Meier T;Meles KG;Mensah G;Meretoja A;Mezgebe H;Miller T;Mirrakhimov E;Mohammed S;Moran AE;Musa KI;Narula J;Neal B;Ngalesoni F;Nguyen G;Obermeyer CM;Owolabi M;Patton G;Pedro J;Qato D;Qorbani M;Rahimi K;Rai RK;Rawaf S;Ribeiro A;Safiri S;Salomon JA;Santos I;Santric Milicevic M;Sartorius B;Schutte A;Sepanlou S;Shaikh MA;Shin MJ;Shishehbor M;Shore H;Silva DAS;Sobngwi E;Stranges S;Swaminathan S;Tabarés-Seisdedos R;Tadele Atnafu N;Tesfay F;Thakur JS;Thrift A;Topor-Madry R;Truelsen T;Tyrovolas S;Ukwaja KN;Uthman O;Vasankari T;Vlassov V;Vollset SE;Wakayo T;Watkins D;Weintraub R;Werdecker A;Westerman R;Wiysonge CS;Wolfe C;Workicho A;Xu G;Yano Y;Yip P;Yonemoto N;Younis M;Yu C;Vos T;Naghavi M;Murray C
在世界许多地区，心血管疾病（CVD）的负担仍不清楚。GBD（全球疾病负担）2015年研究整合了有关疾病发病率、患病率和死亡率的数据，以产生一致的最新心血管负担估计值。根据生命登记和死因推断数据估计CVD死亡率。使用建模软件和来自健康调查、前瞻性队列、卫生系统管理数据和登记的数据估计CVD患病率。残疾生活年（YLD）是通过患病率乘以残疾权重来估计的。通过将年龄特异性CVD死亡乘以参考预期寿命来估计寿命损失年数（YLL）。根据人均收入、教育程度和生育率，为每个地点创建了社会人口指数（SDI）。2015年，估计有4.227亿例CVD病例（95%不确定性区间：4.1553至4.2787亿例）和1792万例CVD死亡（95%不确定性区间：1759至1828万例CVD死亡）。1990年至2015年期间，所有高收入国家和一些中等收入国家的年龄标准化心血管疾病死亡率都有所下降。缺血性心脏病是全球以及世界各地区心血管疾病健康损失的主要原因，其次是中风。随着SDI增加超过0.25，最高的CVD死亡率从女性转移到男性。在SDI >0.75的国家，男女的心血管疾病死亡率均大幅下降。心血管疾病仍然是世界所有地区健康损失的主要原因。在过去25年中，社会人口变化与SDI非常高的地区CVD的急剧下降有关，但在大多数地区只是逐渐下降或没有变化。GBD研究的未来更新可用于指导政策制定者，他们专注于减少非传染性疾病的总体负担和实现CVD的具体全球健康目标。
The burden of cardiovascular diseases (CVDs) remains unclear in many regions of the world. The GBD (Global Burden of Disease) 2015 study integrated data on disease incidence, prevalence, and mortality to produce consistent, up-to-date estimates for cardiovascular burden. CVD mortality was estimated from vital registration and verbal autopsy data. CVD prevalence was estimated using modeling software and data from health surveys, prospective cohorts, health system administrative data, and registries. Years lived with disability (YLD) were estimated by multiplying prevalence by disability weights. Years of life lost (YLL) were estimated by multiplying age-specific CVD deaths by a reference life expectancy. A sociodemographic index (SDI) was created for each location based on income per capita, educational attainment, and fertility. In 2015, there were an estimated 422.7 million cases of CVD (95% uncertainty interval: 415.53 to 427.87 million cases) and 17.92 million CVD deaths (95% uncertainty interval: 17.59 to 18.28 million CVD deaths). Declines in the age-standardized CVD death rate occurred between 1990 and 2015 in all high-income and some middle-income countries. Ischemic heart disease was the leading cause of CVD health lost globally, as well as in each world region, followed by stroke. As SDI increased beyond 0.25, the highest CVD mortality shifted from women to men. CVD mortality decreased sharply for both sexes in countries with an SDI >0.75. CVDs remain a major cause of health loss for all regions of the world. Sociodemographic change over the past 25 years has been associated with dramatic declines in CVD in regions with very high SDI, but only a gradual decrease or no change in most regions. Future updates of the GBD study can be used to guide policymakers who are focused on reducing the overall burden of noncommunicable disease and achieving specific global health targets for CVD.