Risk factors for pancreatic neuroendocrine tumors: a clinic-based case-control study.
Risk factors for pancreatic neuroendocrine tumors: a clinic-based case-control study.
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DOI：
10.1097/mpa.0000000000000234
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发表时间：
2014-11
期刊：
影响因子：
2.9
通讯作者：
Petersen GM
中科院分区：
文献类型：
--
作者：
Halfdanarson TR;Bamlet WR;McWilliams RR;Hobday TJ;Burch PA;Rabe KG;Petersen GM
胰腺神经内分泌肿瘤（PNET）并不常见，人们对其危险因素以及与其他癌症的关联知之甚少。我们评估了已知与胰腺腺癌相关的危险因素是否也与 PNET 相关：吸烟、饮酒、PNET 和其他癌症的家族史以及个人糖尿病史作为潜在的危险因素。将 2000 年至 2011 年间在罗切斯特梅奥诊所就诊的 PNET 患者与进行一般医学评估的对照患者进行比较。患者和对照完成相同的问卷。排除胰岛素瘤和高级别 PNET 后，对 355 例病例进行了评估，其中 309 例与 602 例对照者（2:1）在年龄、性别和居住地区进行了匹配。个人吸烟史与 PNET 无关。病例中饮酒较少见（54% vs. 67%，p<0.001）。病例更有可能报告家庭成员患有肉瘤（p=0.02）、PNET（p=0.02）、胆囊癌（p=0.02）、卵巢癌（p=0.04）和胃癌（p=0.01）。与家庭成员中的其他癌症没有关联。病例报告的糖尿病比对照组更常见（19% vs. 11%，p<0.001）。除糖尿病外，与胰腺腺癌相关的危险因素不是 PNET 的危险因素。
Pancreatic neuroendocrine tumors (PNETs) are uncommon, and little is known about their risk factors and association with other cancers. We evaluated whether risk factors known to be associated with pancreatic adenocarcinoma are also associated with PNETs: smoking, alcohol use, family history of PNET and other cancers, and personal history of diabetes as potential risk factors. Patients with PNETs seen at Mayo Clinic Rochester between 2000 and 2011 were compared to controls seen for a general medical evaluation. Patients and controls completed the same questionnaires. After excluding insulinoma and high-grade PNETs, 355 cases were evaluated, and 309 were matched to 602 controls (2:1) on age, sex, and region of residence. Personal smoking history was not associated with PNETs. Alcohol use was less common among cases (54% vs. 67%, p<0.001). Cases were more likely to report a family member with sarcoma (p=0.02), PNET (p=0.02), gall bladder cancer (p=0.02), ovarian cancer (p=0.04) and gastric cancer (p=0.01). There was no association with other cancers in family members. Diabetes was more commonly reported by cases than controls (19% vs. 11%, p<0.001). With the exception of diabetes, risk factors that are associated with pancreatic adenocarcinoma are not risk factors for PNETs.