Inductive and Deductive Approaches to Acute Cell Injury.
Inductive and Deductive Approaches to Acute Cell Injury.
复制标题
急性细胞损伤的归纳和演绎方法。
DOI：
10.1155/2014/859341
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Huang,Zhi-Feng
中科院分区：
文献类型：
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作者：
DeGracia,DonaldJ;TriAnggraini,Fika;Taha,DoaaTahaMetwally;Huang,Zhi-Feng
许多临床相关形式的急性损伤，如中风、创伤性脑损伤和心肌梗死，已经抵抗了防止损伤后细胞死亡的治疗。 基于损伤系统的生物学特性，临床失败可以与当前使用的诱导模型相关联。在这里，我们对比应用急性细胞损伤的归纳和演绎模型。使用脑缺血作为一个案例研究，我们讨论了归纳推理的局限性，包括无法明确地分配细胞死亡的因果关系和缺乏一个系统的定量框架。这些局限性来自于对损伤系统特异性的定性分子途径的过度强调。我们最近开发的细胞损伤的非线性动力学理论提供了一个通用的，系统的方法，细胞损伤中的吸引子状态和系统参数被用来定量表征急性损伤系统。转移到一个演绎框架的理论，经验和治疗的影响进行了讨论。我们说明了如何演绎的数学框架提供了有形的优势，定性归纳模型的发展，治疗急性损伤的生物系统。
Many clinically relevant forms of acute injury, such as stroke, traumatic brain injury, and myocardial infarction, have resisted treatments to prevent cell death following injury. The clinical failures can be linked to the currently used inductive models based on biological specifics of the injury system. Here we contrast the application of inductive and deductive models of acute cell injury. Using brain ischemia as a case study, we discuss limitations in inductive inferences, including the inability to unambiguously assign cell death causality and the lack of a systematic quantitative framework. These limitations follow from an overemphasis on qualitative molecular pathways specific to the injured system. Our recently developed nonlinear dynamical theory of cell injury provides a generic, systematic approach to cell injury in which attractor states and system parameters are used to quantitatively characterize acute injury systems. The theoretical, empirical, and therapeutic implications of shifting to a deductive framework are discussed. We illustrate how a deductive mathematical framework offers tangible advantages over qualitative inductive models for the development of therapeutics of acutely injured biological systems.