Circadian rhythms and mood disorders: are the phenomena and mechanisms causally related?
Circadian rhythms and mood disorders: are the phenomena and mechanisms causally related?
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DOI：
10.3389/fpsyt.2015.00118
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发表时间：
2015-08-24
影响因子：
4.7
通讯作者：
Bechtel, William
中科院分区：
文献类型：
--
作者：
Bechtel, William
本文回顾了情绪障碍（重度抑郁症、季节性情感障碍和双相情感障碍）患者昼夜节律紊乱的一些令人信服的证据，以及旨在改变昼夜节律的强光等治疗方法可有效治疗这些疾病。与情绪调节有关的大脑区域的神经递质表现出昼夜节律。最初用于识别昼夜节律基因的小鼠模型已被证明是躁狂症的有效模型。虽然这一证据表明昼夜节律改变在情绪障碍中具有病因学作用，但它与其他解释是一致的，包括昼夜节律紊乱和情绪障碍是共同原因的结果，并且两者涉及的基因和蛋白质仅具有多效性作用。有鉴于此，该论文提出了一项建议，即需要哪些证据来建立昼夜节律破坏和情绪障碍之间的直接因果关系。
This paper reviews some of the compelling evidence of disrupted circadian rhythms in individuals with mood disorders (major depressive disorder, seasonal affective disorder, and bipolar disorder) and that treatments such as bright light, designed to alter circadian rhythms, are effective in treating these disorders. Neurotransmitters in brain regions implicated in mood regulation exhibit circadian rhythms. A mouse model originally employed to identify a circadian gene has proven a potent model for mania. While this evidence is suggestive of an etiological role for altered circadian rhythms in mood disorders, it is compatible with other explanations, including that disrupted circadian rhythms and mood disorders are effects of a common cause and that genes and proteins implicated in both simply have pleiotropic effects. In light of this, the paper advances a proposal as to what evidence would be needed to establish a direct causal link between disruption of circadian rhythms and mood disorders.