Bone loss, physical activity, and weight change in elderly women: The Dubbo Osteoporosis Epidemiology Study
Bone loss, physical activity, and weight change in elderly women: The Dubbo Osteoporosis Epidemiology Study
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DOI：
10.1359/jbmr.1998.13.9.1458
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发表时间：
1998-09-01
影响因子：
6.2
通讯作者：
Eisman, JA
中科院分区：
文献类型：
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作者：
Nguyen, TV;Sambrook, PN;Eisman, JA
本研究考察了体力活动、体重和体重变化对老年女性股骨骨丢失与年龄的关系。对参与Dubbo骨质疏松流行病学研究的827名妇女的股骨颈骨密度(BMD)的基线和随访测量进行了重新分析。体力活动基于每天从事各种活动的小时数进行评估，根据预期的耗氧量，骨密度丢失率随着年龄的增加而递增，即60-69，70-79，60-69，70-79，和大于或等于80个年龄组(p<；0.001)。经年龄调整后，不从事体育活动的女性减幅更大(每年-1.4%+/-0.2%；p<；0.001)，而体育活动女性(每年-0.5%+/-0.3%；p=0.15)。更瘦的女性经历了更快的骨质流失，在研究期间体重下降(大于或等于5%)的女性比体重稳定(每年-0.8+/-0.1%)或增加(每年+0.1+/-0.3%；p<；0.01，方差分析)的女性失去了更多的骨质(-1.7+/-0.4%/年)。此外，基线时BMD高(>；0.81g/cm(2))的女性的损失(-1.1+/-0.2%)比中三分位数(1.0+/-0.2%)或下三分位数(-0.5+/-0.3%)的女性更大。骨丢失率的独立预测因素包括年龄、基线骨密度、体重、体重变化和体力活动；通过多元回归分析，这些因素合计可解释骨丢失总方差的13%。结论是，在晚年生活中保持身体活动的生活方式和稳定的体重可能会延缓股骨近端骨丢失，从而有助于降低骨折风险。
The present study examined the effects of physical activity, weight, and weight change on femoral bone loss in relation to age in elderly women. Baseline and follow-up measurements at an average interval of 2.7 years of femoral neck bone mineral density (BMD) were reanalyzed for 827 women who were part of the Dubbo Osteoporosis Epidemiology Study, Physical activity was assessed based on hours per day spent in each of various activities according to its expected oxygen consumption, The rate of loss of BMD progressively increased with age, i.e., -0.6 +/- 0.1, -1.1 +/- 0.2, and -2.1 +/- 0.6% per year (mean +/- SEM) for the 60-69, 70-79, and greater than or equal to 80 age groups, respectively (p < 0.001). After adjustment for age, physically inactive women lost more (-1.4 +/- 0.2% per year; p < 0.001), compared with physically active women (-0.5 +/- 0.3% per year; p = 0.15). Thinner women experienced more rapid bone loss, and women whose weight decreased (greater than or equal to 5%) over the study period lost more bone (-1.7 +/- 0.4% per year) than those whose weight was stable (-0.8 +/- 0.1% per year) or increased (+0.1 +/- 0.3% per year; p < 0.01, analysis of variance). Furthermore, women whose BMD was high (>0.81 g/cm(2)) at baseline experienced greater loss (-1.1 +/- 0.2%) compared with those in the middle tertile (1.0 +/- 0.2%) or lowest tertile (-0.5 +/- 0.3%). Independent predictors of rate of bone loss included age, baseline BMD, weight, weight change, and physical activity; collectively these factors accounted for 13% of total variance of bone loss by multiple regression analysis. It is concluded that a physically active lifestyle and stable weight in the later decades of life may retard proximal femur bone loss and thus contribute to reduction of fracture risk.