Minimal-change glomerulopathy and glomerular visceral epithelial hyperplasia associated with alpha-interferon therapy for cutaneous T-cell lymphoma.
Minimal-change glomerulopathy and glomerular visceral epithelial hyperplasia associated with alpha-interferon therapy for cutaneous T-cell lymphoma.
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与 α-干扰素治疗皮肤 T 细胞淋巴瘤相关的微小病变性肾小球病和肾小球内脏上皮增生。
DOI：
10.1159/000187894
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发表时间：
1994
期刊：
影响因子：
2.5
通讯作者：
Yashpal S Kanwar
中科院分区：
文献类型：
--
作者：
A. Traynor;T. Kuzel;E. Samuelson;Yashpal S Kanwar
一名44岁的男子被诊断为皮肤T细胞淋巴瘤的特点是增殖的CD 4阳性细胞。作为对α-干扰素治疗的反应，他的皮肤病迅速消退。这种改善与肾衰竭的发展有关，其特征是肾病范围的蛋白尿伴间质性肾炎和微小病变肾病。肾活检的显著发现是内脏上皮细胞（足细胞）明显增生。停用干扰素和开始泼尼松治疗后，肾脏疾病明显改善。肾病范围蛋白尿消退，但从未完全消退。该病例说明了淋巴因子介导的肾毒性在淋巴组织增生性疾病中的可能作用。
A 44-year-old man was diagnosed with cutaneous T-cell lymphoma characterized by a proliferation of CD4-positive cells. In response to alpha-interferon therapy, he experienced rapid regression of his cutaneous disease. This improvement was associated with development of renal failure, characterized by nephrotic-range proteinuria with interstitial nephritis and minimal-change nephropathy. The remarkable finding of renal biopsy was marked proliferation of visceral epithelial cells (podocytes). Renal disease improved significantly in response to discontinuation of interferon and initiation of prednisone therapy. Nephrotic range proteinuria regressed, but never completely resolved. This case is illustrative of the probable role for lymphokine-mediated nephrotoxicity in the setting of lymphoproliferative disease.