Animal models for human disc degeneration.
Animal models for human disc degeneration.
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DOI：
10.1016/j.spinee.2005.02.016
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发表时间：
2005-11-01
期刊：
影响因子：
--
通讯作者：
An, Howard S
中科院分区：
文献类型：
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作者：
Singh, Kern;Masuda, Koichi;An, Howard S
尽管退行性椎间盘疾病有明显的损害，但对其发病机制仍缺乏明确的认识。目前，没有特定的模型与人类椎间盘退变的复杂性质相平行。自然发生的动物模型具有的缺点是椎间盘退变率高的基础尚不清楚。虽然在人工动物模型中产生椎间盘退变的干预措施是已知的，但这些干预措施与导致人类椎间盘退变的事件之间的关系尚不清楚。随着生物力学、细胞生物学和分子生物学的最新进展，一种易于复制和有效的动物模型可能有助于解开人类椎间盘退变的复杂级联事件。
Despite the significant impairment associated with degenerative disc disease, a clear understanding of its pathogenesis is still lacking. Currently, no particular model parallels the complex nature of human disc degeneration. Naturally occurring animal models have the drawback that the basis for the high rate of disc degeneration is not known. Although the interventions in artificial animal models that create disc degeneration are known, the relationship of those to the events leading to disc degeneration in humans is not. With the recent progress in biomechanics, cell biology and molecular biology, an easily reproducible and valid animal model may help unlock the complex cascade of events surrounding human disc degeneration.