Reconstitution of Germ Cell Development In Vitro
Reconstitution of Germ Cell Development In Vitro
复制标题
体外生殖细胞发育的重建
DOI：
10.1007/978-981-10-7941-2_1
复制
发表时间：
2018
期刊：
影响因子：
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通讯作者：
Shihori Yokobayashi and Mitinori Saitou
中科院分区：
文献类型：
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作者：
Yamashiro Chika;Sasaki Kotaro;Yokobayashi Shihori;Kojima Yoji;Saitou Mitinori;Shihori Yokobayashi and Mitinori Saitou
哺乳动物生殖细胞的发育始于妊娠早期原始生殖细胞（PGCs）的发育。PGCs向精子或成熟卵母细胞的发育涉及复杂的途径，需要很长的时间，如人类需要10年以上。近年来，利用多能干细胞体外重建生殖细胞发育的研究取得了显著进展。这些体外系统的建立对于解决有关生殖细胞性质的各种生物学问题，以及研究相关疾病和潜在的应用研究具有重要意义。
Mammalian germ cell development begins with the specification of primordial germ cells (PGCs) in the early phase of pregnancy. The development of PGCs to spermatozoa or mature oocytes involves complex pathways and takes a long time, e.g., more than 10 years in humans. Recent researches aimed at reconstituting germ cell development using pluripotent stem cells in vitro have achieved remarkable progress. Establishment of these in vitro systems is of great importance for addressing various biological questions on the nature of germ cells, as well as for studying the associated diseases and potentially for applied research.