HUMAN STUDIES ON THE MU-OPIATE RECEPTOR AGONIST FENTANYL - NEURO-ENDOCRINE AND BEHAVIORAL-RESPONSES
HUMAN STUDIES ON THE MU-OPIATE RECEPTOR AGONIST FENTANYL - NEURO-ENDOCRINE AND BEHAVIORAL-RESPONSES
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DOI：
10.1016/0306-4530(88)90046-7
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发表时间：
1988-01-01
影响因子：
3.7
通讯作者：
DOENICKE, A
中科院分区：
文献类型：
--
作者：
HOEHE, M;DUKA, T;DOENICKE, A
神经内分泌和行为反应的有效μ。阿片受体激动剂芬太尼（FE）在健康男性志愿者中进行了系统的研究。根据随机区组设计，这些志愿者接受不同剂量的FE：0.1 mg/70 kg（n=11）、0.2 mg/70 kg（n =11）、0.25 mg/70 kg（n=8）和生理盐水（n=11）。FE诱导血浆催乳素浓度显著剂量依赖性增加，这在最低剂量下是显著的。与此相反，生长激素显着刺激的最高FE剂量。此外，FE在最低剂量（0.1 mg/70 kg）下诱导血浆皮质醇浓度最大程度降低。同时，在最低FE剂量下也观察到明显的欣快反应。这些结果表明，对所有神经内分泌和行为参数的特定影响。然而，这些参数对不同剂量的FE的不同响应表明这些参数被μ M的微扰调制。受体激动剂FE。
The neuroendocrine and behavioral responses to the potent .mu. opiate receptor agonist Fentanyl (FE) have been systematically investigated in healthy male volunteers. These volunteers received, according to a randomized block design, different doses of FE: 0.1 mg/70 kg (n=11), 0.2 mg/70 kg (n=11), 0.25 mg/70 kg (n=8), and saline (n=11). FE induced a pronounced dose-dependent increase of plasma prolactin concentrations, which was significant at the lowest dose. In contrast, growth hormone was significantly stimulated by the highest FE dose only. Moreover, FE induced a maximum reduction of plasma cortisol concentrations at the lowest dose (0.1 mg/70 kg). In parallel, marked euphoric responses were also observed at this lowest FE dose. These results suggest a .mu. specific influence on all neuroendocrine and behavioral parameters investigated. Different responses of these parameters to different doses of FE, however, suggest a differential modulation of these parameters by the .mu. receptor agonist FE.