EVIDENCE THAT NIGRAL GABA MEDIATES BEHAVIORAL-RESPONSES ELICITED BY STRIATAL DOPAMINE RECEPTOR STIMULATION
EVIDENCE THAT NIGRAL GABA MEDIATES BEHAVIORAL-RESPONSES ELICITED BY STRIATAL DOPAMINE RECEPTOR STIMULATION
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DOI：
10.1016/0024-3205(78)90237-0
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发表时间：
1978-01-01
期刊：
影响因子：
6.1
通讯作者：
GESSA, GL
中科院分区：
文献类型：
--
作者：
DICHIARA, G;MORELLI, M;GESSA, GL
GABA受体阻滞剂（印防己毒素或荷包牡丹碱）的双侧黑质内给药可诱发紧张症，而阿扑吗啡（一种多巴胺（DA）受体激动剂）的给药无法克服紧张症。GABA受体阻滞剂的单侧intrinigral管理同侧的黑质纹状体DA-神经元损伤60 H-DA，拮抗阿扑吗啡产生的对侧转向。结果表明，纹状体DA受体刺激引起的行为反应是通过GABA介导的抑制网状部神经元的影响。
Bilateral intranigral administration of GABA-receptor blockers (picrotoxin or bicuculline) elicits catatonia not surmountable by administration of apomorphine, a dopamine (DA)-receptor agonist. Unilateral intranigral administration of GABA-receptor blockers ipsilateral to a lesion of nigro-striatal DA-neurons induced with 60H-DA, antagonizes the contralateral turning produced by apomorphine. The results indicate that behavioural responses elicited by striatal DA-receptor stimulation are effected through a GABA-mediated inhibition of pars reticulata neurons.