DOLICHOL MONOPHOSPHATE GLUCOSE - AN INTERMEDIATE IN GLUCOSE TRANSFER IN LIVER
DOLICHOL MONOPHOSPHATE GLUCOSE - AN INTERMEDIATE IN GLUCOSE TRANSFER IN LIVER
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DOI：
10.1073/pnas.66.1.153
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发表时间：
1970-01-01
影响因子：
11.1
通讯作者：
LELOIR, LF
中科院分区：
文献类型：
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作者：
BEHRENS, NH;LELOIR, LF
已发现肝脏微粒体部分可催化葡萄糖从 UDPG 转移至脂质受体，该受体似乎与通过多乙醇化学磷酸化获得的化合物相同。形成的物质（多萜醇单磷酸葡萄糖）对酸不稳定，通过碱处理可产生 1,6-脱水葡聚糖。它可以被酶系统用作底物，产生糖蛋白，随后水解成葡萄糖。
The microsomal fraction of liver has been found to catalyze glucose transfer from UDPG to a lipid acceptor which appears to be identical to the compound obtained by chemical phosphorylation of dolichol. The substance formed (dolichol monophosphate glucose) is acid labile and yields 1,6-anhydroglucosan by alkaline treatment. It can be used as substrate by the enzyme system yielding a glucoprotein which is subsequently hydrolyzed to glucose.