Circulating enterolactone and risk of endometrial cancer.
Circulating enterolactone and risk of endometrial cancer.
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循环肠内酯和子宫内膜癌的风险。
DOI：
10.1002/ijc.22140
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发表时间：
2006
影响因子：
6.4
通讯作者：
中科院分区：
文献类型：
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作者：
Zeleniuch-Jacquotte,Anne;Lundin,Eva;Micheli,Andrea;Koenig,KarenL;Lenner,Per;Muti,Paola;Shore,RoyE;Johansson,Ingegerd;Krogh,Vittorio;Lukanova,Annekatrin;Stattin,Pär;Afanasyeva,Yelena;Rinaldi,Sabina;Arslan,AlanA;Kaaks,Rudolf;
有人认为植物雌激素可以预防激素依赖性癌症。木脂素是西方饮食中主要的植物雌激素。我们进行了一项关于子宫内膜癌和人体主要木脂素肠内酯循环水平的前瞻性研究。设计是一项病例对照研究，嵌套在纽约、瑞典和意大利的3项前瞻性队列研究中。在入组时采集血清或血浆样本，并储存在−80°C下。共纳入153例病例，诊断时间中位数为献血后5.3年，271例匹配对照。病例组（中位数，19.2 nmol/L）和对照组（18.5 nmol/L）之间的循环肠内酯无差异。调整体重指数后，肠内酯最高三分位数与最低三分位数的比值比为1.2（95% CI，0.7-2.0;趋势p = 0.53）。在绝经前和绝经后女性中均观察到缺乏相关性。在健康绝经后妇女中，未观察到肠内酯与循环雌激素或SHBG之间的相关性。这些结果不支持循环木脂素的保护作用，在所观察到的水平范围内，对子宫内膜癌。© 2006 Wiley利斯公司
It has been suggested that phytoestrogens protect against hormone‐dependent cancers. Lignans are the main class of phytoestrogens in Western diets. We conducted a prospective study of endometrial cancer and circulating levels of the main human lignan, enterolactone. The design was a case–control study nested within 3 prospective cohort studies, in New York, Sweden and Italy. Serum or plasma samples had been collected at enrollment and stored at −80°C. A total of 153 cases, diagnosed a median of 5.3 years after blood donation, and 271 matched controls were included. No difference in circulating enterolactone was observed between cases (median, 19.2 nmol/L) and controls (18.5 nmol/L). Adjusting for body mass index, the odds ratio for the top tertile of enterolactone, as compared to the lowest was 1.2 (95% CI, 0.7–2.0;pfor trend = 0.53). Lack of association was observed in both pre‐ and postmenopausal women. No correlation was observed between enterolactone and circulating estrogens or SHBG in healthy postmenopausal women. These results do not support a protective role of circulating lignans, in the range of levels observed, against endometrial cancer. © 2006 Wiley‐Liss, Inc.