Anaphylactoid reaction to intravenous methylprednisolone in a patient with multiple sclerosis
Anaphylactoid reaction to intravenous methylprednisolone in a patient with multiple sclerosis
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多发性硬化症患者静脉注射甲基泼尼松龙的过敏反应
DOI：
10.1136/jnnp.63.6.813
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发表时间：
1997
影响因子：
11
通讯作者：
P. Van Der Valk
中科院分区：
文献类型：
--
作者：
J. V. D. van den Berg;O. Hommes;E. Wuis;S. Stapel;P. Van Der Valk
多发性硬化症的恶化用短疗程的高剂量静脉注射甲基强的松龙治疗。静脉注射甲泼尼龙主要有轻微的副作用，如短暂的脸红、短暂的味觉障碍、失眠和轻微的体重增加静脉注射甲基强的松龙治疗后出现的类过敏反应仅发生在一例多发性硬化症患者身上我们报告了一位多发性硬化症患者，他在大剂量静脉注射甲基强的松龙治疗后发生了类过敏反应。进一步的研究是为了阐明静脉注射甲基强的松龙后这种反应的机制。
Exacerbations in multiple sclerosis are treated with short courses of high dose intravenous methylprednisolone. Treatment with intravenous methylprednisolone has mainly minor side effects such as transient flushing, a brief disturbance of taste, insomnia, and mild weight gain.1 An anaphylactoid reaction after intravenous methylprednisolone treatment has been described in only one patient with multiple sclerosis.2 We report on a patient with multiple sclerosis who developed an anaphylactoid reaction on high dose intravenous methylprednisolone treatment. Additional investigations were performed to elucidate the mechanism of this reaction to intravenous methylprednisolone.
A 44 year old woman was admitted to our clinic because of progressive multiple sclerosis. One year before admission she had developed paresis of the legs, and subsequently of the arms. She became incontinent for urine and faeces. On admission she also complained of numb feelings and muscle cramps in her legs. The medical history mentioned hypertension for which she used propranolol and hydrochlorothiazide. The family history was negative for multiple sclerosis. On examination there was vertical nystagmus, slight paresis of the arms, paraplegia, incoordination of the arms, and loss of sensation from a mid-thoracic level. The tendon reflexes of the legs were very brisk, …