Association of Central Obesity With the Severity and Audiometric Configurations of Age-related Hearing Impairment
Association of Central Obesity With the Severity and Audiometric Configurations of Age-related Hearing Impairment
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DOI：
10.1038/oby.2009.66
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发表时间：
2009-09-01
期刊：
影响因子：
6.9
通讯作者：
Yang, Wei-Shiung
中科院分区：
文献类型：
--
作者：
Hwang, Juen-Haur;Wu, Chen-Chi;Yang, Wei-Shiung
为了研究中枢性肥胖对年龄相关性听力损害（ARHI）的严重程度和特征的影响，我们招募了690名正常或对称感音神经性听力损失（SNHL）的成年受试者。分析年龄、性别、形态学、生活习惯、全身性疾病和环境噪声暴露对低、高频纯音平均听力水平的影响。在调整了年龄、性别、全身性疾病和其他变量后，腰围（WC）与PTA-low和PTA-high呈显著正相关。在女性中，PTA-low和PTA-high仅与年龄呈显著正相关，与WC等变量无显著正相关。然而，在55岁以上的女性受试者中，pta高与WC呈显著正相关。在男性中，WC、年龄和噪音暴露与pta高和低均显示出显著正相关，主要发生在55岁以下的受试者中。在多元逐步线性回归分析中同时考虑WC和BMI， WC与55岁以下男性的PTA-low和PTA-high呈显著正相关，而BMI与此无关，而在55岁以上女性中，WC与PTA-high呈边缘显著正相关。然而，中枢性肥胖在年龄和性别上对听力图模式没有显著影响。我们的研究结果表明，即使在BMI调整后，WC仍然是ARHI的独立危险因素，特别是在55岁以下男性的低频率和高频率以及55岁以上女性受试者的高频率中。
To investigate the effect of central obesity on the severity and characteristics of age-related hearing impairment (ARHI), we recruited 690 adult subjects with normal or symmetrical sensorineural hearing loss (SNHL). The effects of age, gender, morphometry, habits, systemic diseases, and environmental noise exposure on average pure tone hearing level at low frequencies (pure tone audiometry (PTA)-low) and high frequencies (PTA-high) were analyzed. After adjusting for age, gender, systemic disease, and other variables, waist circumference (WC) showed a significant positive association with PTA-low and PTA-high. In females, PTA-low and PTA-high only showed significant positive association with age, but not with WC or other variables. However, PTA-high showed a positive association with borderline significance with WC in female subjects older than 55. In males, WC as well as age and noise exposure showed significant positive associations with both PTA-low and PTA-high, primarily in subjects younger than 55. When both WC and BMI were taken into account in a backward stepwise multivariate linear regression analysis, WC, but not BMI, showed a significant positive association with PTA-low and PTA-high in males younger than 55, and with PTA-high with borderline significance in females older than 55. However, the audiogram patterns were not significantly affected by central obesity in either age or gender. Our results suggest that WC was, even after adjustment for BMI, an independent risk factor of ARHI, particularly for low and high frequencies in males younger than 55 and for high frequencies in female subjects older than 55.