Lymphangiogenesis Guidance Mechanisms and Therapeutic Implications in Pathological States of the Cornea.
Lymphangiogenesis Guidance Mechanisms and Therapeutic Implications in Pathological States of the Cornea.
复制标题
角膜病理状态的淋巴管生成引导机制和治疗意义。
作者：
角膜淋巴管生成是在包括干眼病和角膜移植排斥在内的角膜的几种炎性病理中观察到的新血管形成的一个组成部分。损伤后，角膜（淋巴）血管生成豁免受损，允许血管和淋巴管长入先前无血管的角膜。虽然病理性角膜血管生成的机制已经得到很好的描述，但角膜中淋巴管生成的指导机制的知识相对较少。一般而言，各种信号传导途径参与淋巴管生成指导，每种信号传导途径影响淋巴管发育的一个或多个阶段。大多数引导角膜淋巴管生长或消退的内源性因子通过血管内皮生长因子C信号通路（淋巴管生成的中心调节因子）起作用。几种外源性因子最近被重新利用，并显示出调节角膜淋巴管生成，揭示了以前不知道的影响淋巴管引导的独特信号通路。对相关淋巴管生成指导机制的深刻理解可以促进角膜病理学的靶向抗淋巴管生成疗法的发展。在这篇综述中，我们研究了目前的知识，淋巴引导线索，其调节炎症状态的角膜，最近发现的抗淋巴管生成的治疗方式。
Corneal lymphangiogenesis is one component of the neovascularization observed in several inflammatory pathologies of the cornea including dry eye disease and corneal graft rejection. Following injury, corneal (lymph)angiogenic privilege is impaired, allowing ingrowth of blood and lymphatic vessels into the previously avascular cornea. While the mechanisms underlying pathological corneal hemangiogenesis have been well described, knowledge of the lymphangiogenesis guidance mechanisms in the cornea is relatively scarce. Various signaling pathways are involved in lymphangiogenesis guidance in general, each influencing one or multiple stages of lymphatic vessel development. Most endogenous factors that guide corneal lymphatic vessel growth or regression act via the vascular endothelial growth factor C signaling pathway, a central regulator of lymphangiogenesis. Several exogenous factors have recently been repurposed and shown to regulate corneal lymphangiogenesis, uncovering unique signaling pathways not previously known to influence lymphatic vessel guidance. A strong understanding of the relevant lymphangiogenesis guidance mechanisms can facilitate the development of targeted anti-lymphangiogenic therapeutics for corneal pathologies. In this review, we examine the current knowledge of lymphatic guidance cues, their regulation of inflammatory states in the cornea, and recently discovered anti-lymphangiogenic therapeutic modalities.
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影响因子：
11.8
作者：
Bazigou, Eleni;Xie, Sherry;Chen, Chun;Weston, Anne;Miura, Naoyuki;Sorokin, Lydia;Adams, Ralf;Muro, Andres F.;Sheppard, Dean;Makinen, Taija
通讯作者：
Makinen, Taija
影响因子：
29
作者：
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Mazzone, Massimiliano
影响因子：
10.5
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Cha B;Geng X;Mahamud MR;Fu J;Mukherjee A;Kim Y;Jho EH;Kim TH;Kahn ML;Xia L;Dixon JB;Chen H;Srinivasan RS
通讯作者：
Srinivasan RS
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影响因子：
3.7
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Gao M;Liu Y;Xiao Y;Han G;Jia L;Wang L;Lei T;Huang Y
通讯作者：
Huang Y
影响因子：
8.2
作者：
Chang, Chi-hao;Huang, Yuan-li;Lee, Hsinyu
通讯作者：
Lee, Hsinyu