The utility of biomarkers in the diagnosis and therapy of inflammatory bowel disease.
The utility of biomarkers in the diagnosis and therapy of inflammatory bowel disease.
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DOI：
10.1053/j.gastro.2010.11.058
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发表时间：
2011-05
期刊：
影响因子：
29.4
通讯作者：
Lewis JD
中科院分区：
文献类型：
--
作者：
Lewis JD
粪便和血清学生物标志物可用于炎症性肠病（IBD）的诊断和管理。粪便标志物如钙卫蛋白和乳铁蛋白已被研究其识别IBD患者、评估疾病活动性和预测复发的能力。针对酿酒酵母和核周抗神经细胞胞质蛋白的抗体已被用于IBD的诊断，以区分克罗恩病（CD）和溃疡性结肠炎，并预测CD并发症的风险。c-反应蛋白和红细胞沉降率的测试已被用于评估炎症过程和预测IBD进展的过程。可以测量药物代谢物和针对治疗剂的抗体的水平，以确定患者对治疗没有反应的原因并选择替代治疗。本文综述了生物标志物检测的潜力，以改善治疗策略和挑战，他们的使用和发展。
Fecal and serologic biomarkers can be used in the diagnosis and management of inflammatory bowel disease (IBD). Fecal markers such as calprotectin and lactoferrin have been studied for their ability to identify patients with IBD, assess disease activity, and predict relapse. Antibodies against Saccharomyces cerevisiae and perinuclear antineutrophil cytoplasmic proteins have been used in diagnosis of IBD, to distinguish Crohn's disease (CD) from ulcerative colitis, and to predict the risk of complications of CD. Tests for c-reactive protein and erythrocyte sedimentation rate have been used to assess inflammatory processes and predict the course of IBD progression. Levels of drug metabolites and antibodies against therapeutic agents might be measured to determine why patients do not respond to therapy and to select alternative treatments. This review addresses the potential for biomarker assays to improve treatment strategies and challenges to their use and development.
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DOI：
10.1016/j.cgh.2008.04.032
发表时间：
2008-10
期刊：
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
影响因子：
--
作者：
Dubinsky MC;Kugathasan S;Mei L;Picornell Y;Nebel J;Wrobel I;Quiros A;Silber G;Wahbeh G;Katzir L;Vasiliauskas E;Bahar R;Otley A;Mack D;Evans J;Rosh J;Hemker MO;Leleiko N;Crandall W;Langton C;Landers C;Taylor KD;Targan SR;Rotter JI;Markowitz J;Hyams J;Western Regional Pediatric IBD Research Alliance;Pediatric IBD Collaborative Research Group;Wisconsin Pediatric IBD Alliance
通讯作者：
Wisconsin Pediatric IBD Alliance
影响因子：
9.8
作者：
Dubinsky, MC;Lin, YC;Yang, HY
通讯作者：
Yang, HY
影响因子：
8
作者：
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通讯作者：
Winter, Harland S.
影响因子：
5.2
作者：
BEATTIE, RM;WALKERSMITH, JA;MURCH, SH
通讯作者：
MURCH, SH
DOI：
10.1038/ajg.2010.9
发表时间：
2010-05
期刊：
The American journal of gastroenterology
影响因子：
--
作者：
Afif W;Loftus EV Jr;Faubion WA;Kane SV;Bruining DH;Hanson KA;Sandborn WJ
通讯作者：
Sandborn WJ