The refractive development of untreated eyes of rhesus monkeys varies according to the treatment received by their fellow eyes
The refractive development of untreated eyes of rhesus monkeys varies according to the treatment received by their fellow eyes
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DOI：
10.1016/s0042-6989(98)00177-1
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发表时间：
1999-05-01
期刊：
影响因子：
1.8
通讯作者：
Boothe, RG
中科院分区：
文献类型：
--
作者：
Bradley, DV;Fernandes, A;Boothe, RG
为了确定一只眼睛的视觉体验可能影响其对侧眼睛的屈光发育的程度，我们分析了接受不同类型的单侧图案剥夺的猴子的未治疗（UT）眼睛的数据。受试者为15只幼年恒河猴，3个治疗组各5只猴：无晶状体眼伴光学矫正（AC）、无晶状体眼伴矫正（ANC）和用不透明接触透镜（OC）遮挡的眼睛。在全身麻醉下，屈光不正（D）通过睫状肌麻痹视网膜检影法测定，眼轴长度（mm）通过A-扫描超声测量。对于UT眼的屈光不正的测量，根据对侧眼的治疗，组间存在显著的主效应，F（2，12）= 6.6。而与AC对侧眼配对的UT眼（平均值=+4.2D）比年龄匹配的正常猴的眼（平均值=+2.4D）显著更远视，t（25）= 2.5，与OC对侧眼配对的UT眼（平均值=-0.5D）比正常猴的眼显著更近视，t（25）=-9。UT眼与ANC对侧眼配对（平均值=+1.9 D）与正常眼无显著差异。对于轴向长度的测量，组间也存在显著的主效应，F（2，12）= 6.9。与AC对侧眼配对的UT眼（平均= 16.9 mm）显著短于年龄匹配的正常猴的眼（平均= 17.5 mm），t（25）= 2.3，与OC对侧眼配对的UT眼（平均= 18.1 mm）显著长于正常猴的眼，t（25）= 2.3。UT眼与ANC对侧眼配对（平均值= 17.5 mm）与正常猴的眼无显著差异。UT眼的眼轴长度和屈光不正的测量值也彼此显著相关，可能表明屈光不正的差异是由于眼轴长度的差异，r =-0.8。目前的数据表明，尽管正常的视觉体验，UT眼睛可以有他们的屈光发展改变，系统地，简单地作为一个功能的类型的图案剥夺收到他们的同胞的眼睛。这些数据增加了越来越多的证据表明，有一个眼间机制，是积极的正视化。因此，未来的眼睛生长模型将需要考虑：（1）视觉输入对生长眼睛的直接影响;以及（2）来自另一只眼睛的间接影响。(C)1999爱思唯尔科技有限公司。保留所有权利。
To determine the extent to which the visual experience of one eye may influence the refractive development of its fellow eye, we analyzed the data of untreated (UT) eyes of monkeys that received different types of unilateral pattern deprivation. Subjects were 15 juvenile rhesus monkeys, with five monkeys in each of three treatment groups: aphakic eyes with optical correction (AC), aphakic eyes with no correction (ANC), and eyes that were occluded with an opaque contact lens (OC). Under general anaesthesia, refractive error (D) was determined by cycloplegic retinoscopy and axial length (mm) was determined with A-scan ultrasonography. For measurements of refractive error of the UT eyes, there was a significant main effect of groups according to the treatment of the fellow eyes, F(2, 12) = 6.6. While UT eyes paired with AC fellow eyes (mean = + 4.2 D) were significantly more hyperopic than the eyes of age-matched normal monkeys (mean = + 2.4 D), t(25), = 2.5, UT eyes paired with OC fellow eyes (mean = - 0.5 D) were significantly more myopic than the eyes of normal monkeys, t(25) = - 9. UT eyes paired with ANC fellow eyes (mean = + 1.9 D) were not significantly different from normal eyes. For measurements of axial length there was also a significant main effect of groups, F(2, 12) = 6.9. While UT eyes paired with AC fellow eyes (mean = 16.9 mm) were significantly shorter than the eyes of age-matched normal monkeys (mean = 17.5 mm), t(25)= 2.3, UT eyes paired with OC fellow eyes (mean = 18.1 mm) were significantly longer than the eyes of normal monkeys, t(25) = 2.3. UT eyes paired with ANC fellow eyes (mean = 17.5 mm) were not significantly different from the eyes of normal monkeys. The measurements of axial length and of refractive error of the UT eyes were also significantly correlated with one another, probably indicating that the differences in refractive error were due to differences in axial length, r = - 0.8. The present data reveal that despite normal visual experience, UT eyes can have their refractive development altered, systematically, simply as a function of the type of pattern deprivation received by their fellow eyes. These data add to the growing evidence that there is an interocular mechanism that is active during emmetropization. As a consequence, future models of eye growth will need to consider both: (1) the direct influence of visual input on the growing eye; as well as (2) the indirect influence coming from the fellow eye. (C) 1999 Elsevier Science Ltd. All rights reserved.