T-Cell Levels Are Prognostic in Mantle Cell Lymphoma
T-Cell Levels Are Prognostic in Mantle Cell Lymphoma
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DOI：
10.1158/1078-0432.ccr-14-0889
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发表时间：
2014-12-01
影响因子：
11.5
通讯作者：
Sander, Birgitta
中科院分区：
文献类型：
--
作者：
Nygren, Lina;Wasik, Agata M.;Sander, Birgitta
目的：本研究的目的是探讨 T 细胞亚群对套细胞淋巴瘤 (MCL) 病理和临床特征（包括疾病结果）的影响。实验设计：使用流式细胞术在诊断性 MCL (n = 153) 和反应性 (n = 26) 淋巴结活检中研究细胞群。评估肿瘤细胞、T 细胞、T 细胞亚群的水平和 CD4:CD8 比率，并将其与病理和临床参数相关。结果：具有弥漫性和结节性组织学亚型的 MCL 病例比具有套区生长模式的病例显示出较低水平的 T 细胞，尤其是 CD4(+) T 细胞。结节亚型中的 CD3 和 CD4 水平均低于地幔区 (P = 0.007; P = 0.003)，并且与结节亚型相比，弥漫性亚型中 (P = 0.022; P = 0.015)。 CD4:CD8比率与肿瘤细胞增殖呈负相关(P = 0.003)。较高水平的CD3(+)和CD4(+) T细胞以及较高的CD4:CD8比率与惰性疾病相关(P分别为0.043、0.021和0.003)。在单变量分析中，高 CD4:CD8 比率（但与组织学亚型无关）与较长的总生存期 (OS) 相关。在多变量分析中，CD4:CD8 比率与 OS 相关，独立于套细胞淋巴瘤国际预后指数 (MIPI) 和高 p53 表达 (P = 0.023)。结论：惰性 MCL 中 CD3(+)、CD8(+)、特别是 CD4(+) T 细胞水平较高，并且随着组织学更具侵袭性而降低，如弥漫性生长模式所反映的那样。高 CD4:CD8 比率与其他高风险预后因素独立相关，且 OS 较长，表明 T 细胞在 MCL 中具有预后作用。 (C) 2014 年 AACR。
Purpose: The purpose of this study was to investigate the impact of T-cell subsets on pathologic and clinical features including disease outcome in mantle cell lymphoma (MCL). Experimental Design: Cell populations were investigated using flow cytometry in diagnostic MCL (n = 153) and reactive (n = 26) lymph node biopsies. Levels of tumor cells, T cells, T-cell subsets, and the CD4:CD8 ratio were assessed and related to pathologic and clinical parameters. Results: MCL cases with diffuse and nodular histologic subtypes showed lower levels of T cells, especially CD4(+) T cells, than those with mantle zone growth pattern. Both CD3 and CD4 levels were lower in the nodular subtype than in mantle zone (P = 0.007; P = 0.003) and in the diffuse compared with the nodular subtype (P = 0.022; P = 0.015). The CD4:CD8 ratios were inversely correlated to tumor cell proliferation (P = 0.003). Higher levels of CD3(+) and CD4(+) T cells and higher CD4:CD8 ratios were associated with indolent disease (P = 0.043, 0.021, and 0.003 respectively). In univariate analysis, a high CD4:CD8 ratio, but not the histologic subtype, was correlated to longer overall survival (OS). In multivariate analysis, the CD4:CD8 ratio correlated with OS independently of Mantle Cell Lymphoma International Prognostic Index (MIPI) and high p53 expression (P = 0.023). Conclusion: CD3(+), CD8(+), and particularly CD4(+) T-cell levels are higher in indolent MCL and decrease with more aggressive histology as reflected by a diffuse growth pattern. High CD4:CD8 ratio correlated independently of other high-risk prognostic factors with longer OS, suggesting a prognostic role for T cells in MCL. (C) 2014 AACR.