Nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging allows precise image-guided tumor-removal surgery
Nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging allows precise image-guided tumor-removal surgery
复制标题
纳米颗粒介导的放射性药物激发荧光分子成像可实现精确的图像引导肿瘤切除手术
DOI：
10.1016/j.nano.2017.01.005
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发表时间：
2017-05-01
影响因子：
5.4
通讯作者：
Xu, Wanhai
中科院分区：
文献类型：
--
作者：
Hu, Zhenhua;Chi, Chongwei;Xu, Wanhai
荧光分子成像技术在光学影像引导肿瘤手术的临床前和临床研究中得到了积极的探索，受到了广泛的关注。然而，由于外部光激发导致的低信噪比，荧光图像引导肿瘤手术的效果可能会受到影响。本研究提出了一种新的纳米粒子介导的放射性药物激发荧光（REF）图像引导癌症手术策略，该策略利用放射性药物发出的伽马射线和切伦科夫发光对氧化铕纳米粒子进行内部双激发。采用皮下乳腺癌4 T1肿瘤模型、正异性和正异性异位肝癌荷瘤小鼠，系统评价了新型图像引导手术技术的性能。结果表明，新型REF图像引导的肿瘤手术技术在检测不可见的超小型肿瘤（甚至小于1mm）和残余肿瘤组织方面表现出高性能。我们的研究证明了新型图像引导癌症手术在精确切除肿瘤方面的巨大潜力。(C) 2017爱思唯尔公司版权所有。
Fluorescent molecular imaging technique has been actively explored for optical image-guided cancer surgery in pre-clinical and clinical research and has attracted many attentions. However, the efficacy of the fluorescent image-guided cancer surgery can be compromised by the low signal-to-noise ratio caused by the external light excitation. This study presents a novel nanoparticle-mediated radiopharmaceutical-excited fluorescent (REF) image-guided cancer surgery strategy, which employs the internal dual-excitation of europium oxide nanoparticles through both gamma rays and Cerenkov luminescence emitted from radiopharmaceuticals. The performance of the novel image-guided surgery technique was systematically evaluated using subcutaneous breast cancer 4 T1 tumor models, orthotropic and orthotropic-ectopic hepatocellular carcinoma tumor-bearingmice. The results reveal that the novel REF image-guided cancer surgery technique exhibits high performance of detecting invisible ultra-small size tumor (even less than 1 mm) and residual tumor tissue. Our study demonstrates the high potential of the novel image-guided cancer surgery for precise tumor resection. (C) 2017 Elsevier Inc. All rights reserved.