Malignant transformation of gastric hyperplastic polyps: Alteration of phenotypes, proliferative activity, and p53 expression
Malignant transformation of gastric hyperplastic polyps: Alteration of phenotypes, proliferative activity, and p53 expression
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DOI：
10.1053/hupa.2002.126874
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发表时间：
2002-10-01
期刊：
影响因子：
3.3
通讯作者：
Tsuneyoshi, M
中科院分区：
文献类型：
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作者：
Yao, T;Kajiwara, M;Tsuneyoshi, M
本研究旨在阐明胃增生性息肉恶性转化的机制，重点从表型表达、细胞增殖、p53过表达等方面进行研究。本研究选择22例胃增生性息肉伴肿瘤灶。根据免疫组化染色（人胃粘蛋白[HGM]、MUC2、CD10）将表型分为3型（G型，胃型；I型，不完全肠型；I型，完全肠型）。同时检测Ki-67的细胞增殖活性和p53蛋白的过表达。其中11例病变包含癌成分（CA，维也纳分类5类），其中6例伴低级别发育不良（LGD， 3类），4例伴高级别发育不良（HGD， 4类）。另外2个仅由高梯度梯度组成，其余9个由低梯度梯度和高梯度梯度组成。结果识别出15个LGD、15个HGD和11个CA组分。15个LGD组件分为1g型和14个incomp I型。所有增生性成分均表达HGM，其中5例（22.7%）伴有局灶性肠化生。MUC2表达证明了这一点，而肠道化经常发生在肿瘤成分中（93%的LGD， 53%的HGD和64%的CA成分）。增生性标记指数为22.2%，LGD为42.2%，HGD为55.7%，CA组分为53.9%。p53蛋白过表达在所有增生中均未被发现，在40%的LGD、60%的HGD和45%的CA组中均未被发现。这些结果提示发育不良-癌序列在增生性息肉恶性转化中的重要性。有趣的是，肠化经常发生在肿瘤转化过程中，尽管在周围的增生性成分中并不常见。版权所有，爱思唯尔科学（美国）。版权所有。
The aim of this study was to clarify the mechanism of malignant transformation of gastric hyperplastic polyps, focusing on phenotypic expression, cell proliferation, and p53 overexpression. Twenty-two lesions of gastric hyperplastic polyps with neoplastic foci were selected for this study. The phenotypes were divided into 3 types (G, gastric; incomp I, incomplete intestinal; and comp I, complete intestinal), according to immunohistochemical stains (human gastric mucin [HGM], MUC2, and CD10). The cell proliferative activity by Ki-67 and overexpression of p53 protein were also examined. Eleven of these lesions contained carcinoma components (CA, category 5 by the Vienna classification), 6 of which were accompanied by low-grade dysplasia (LGD, category 3) and 4 of which were accompanied by high-grade dysplasia (HGD, category 4). Another 2 were composed only of HGD, and the remaining 9 were composed of both LGD and HGD components. As a result, 15 LGD, 15 HGD, and 11 CA components were recognized. The 15 LGD components were classified as 1 G type and 14 incomp I type. All hyperplastic components expressed HGM, 5 (22.7%) of which were accompanied by focal intestinal metaplasia. demonstrated by MUC2 expression, whereas intestinalization frequently occurred in neoplastic components (93% of LGD, 53% of HGD, and 64% of CA components). The labeling index was 22.2% in hyperplastic, 42.2% in LGD, 55.7% in HGD, and 53.9% in CA components. p53 protein overexpression was recognized in none of hyperplastic, in 40% of the LGD, in 60% of the HGD, and in 45% of the CA components. These results suggest the importance of the dysplasia-carcinoma sequence in malignant transformation of hyperplastic polyps. Interestingly, intestinalization frequently occurs during neoplastic transformation, although it is not common in the surrounding hyperplastic components. Copyright 2002, Elsevier Science (USA). All rights reserved.