THE POLYOXYETHYLENE POLYOXYPROPYLENE BLOCK COPOLYMER POLOXAMER-407 SELECTIVELY REDIRECTS INTRAVENOUSLY INJECTED MICROSPHERES TO SINUSOIDAL ENDOTHELIAL-CELLS OF RABBIT BONE-MARROW
THE POLYOXYETHYLENE POLYOXYPROPYLENE BLOCK COPOLYMER POLOXAMER-407 SELECTIVELY REDIRECTS INTRAVENOUSLY INJECTED MICROSPHERES TO SINUSOIDAL ENDOTHELIAL-CELLS OF RABBIT BONE-MARROW
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DOI：
10.1016/0014-5793(92)80655-z
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发表时间：
1992-06-22
期刊：
影响因子：
3.5
通讯作者：
DAVIS, SS
中科院分区：
文献类型：
--
作者：
PORTER, CJH;MOGHIMI, SM;DAVIS, SS
静脉给药后，通过用嵌段共聚物泊洛沙姆-407（一种非离子表面活性剂）涂覆其表面，可以将小胶体颗粒（直径150 nm及以下）特异性地重定向至兔骨髓。包被的胶体被骨髓的窦状内皮细胞隔离，并在这些细胞内的致密体中积累。骨髓内皮细胞对泊洛沙姆-407包被胶体的摄取表明，由聚合物的聚氧乙烯链段对颗粒-细胞相互作用施加的空间排斥屏障显然可以通过与细胞表面的特定相互作用机制克服。这种显著的吸收不能用与泊洛沙姆-467类似结构的其他嵌段共聚物实现。目前的模型的应用程序的药物载体的位点特异性靶向骨髓和选择性地定植在骨髓内皮细胞的肿瘤转移的粘附的预防进行了讨论。
Small colloidal particulates (150 nm and below, in diameter) can be redirected specifically to the rabbit bone marrow following intravenous administration by coating their surface with the block co-polymer poloxamer-407, a non-ionic surfactant. The coated colloids are sequestered by the sinusoidal endothelial cells of the bone marrow and are accumulated in dense bodies within these cells. The uptake of poloxamer-407-coated colloids by marrow endothelial cells suggests that the steric repulsive barrier, imposed by the polyoxyethylene segment of the polymer, to particle-cell interaction can apparently be overcome by a specific interaction mechanism(s) with the cell surface. Such a dramatic uptake cannot be achieved with other block co-polymers of similar structure to poloxamer-467. The application of the current model for the site-specific targeting of drug carriers to bone marrow and the prevention of the adherence of metastases of tumours which selectively colonize the bone marrow endothelium is discussed.