Deep learning analysis of clinical course of primary nephrotic syndrome: Japan Nephrotic syndrome cohort study (JNSCS).
Deep learning analysis of clinical course of primary nephrotic syndrome: Japan Nephrotic syndrome cohort study (JNSCS).
复制标题
原发性肾病综合征临床病程的深度学习分析：日本肾病综合征队列研究（JNSCS）。
DOI：
10.1159/000527900
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发表时间：
2022
影响因子：
2.3
通讯作者：
Masutani K et al.
中科院分区：
文献类型：
--
作者：
Kimura T;Yamamoto R;Yoshino M;Sakate R;Imai E;Maruyama S;Yokoyama H;Sugiyama H;Nitta K;Tsukamoto T;Uchida S;Takeda A;Sato T;Wada T;Hayashi H;Akai Y;Fukunaga M;Tsuruya K;Masutani K et al.
IntroductionTreating diabetic nephropathy with low-density lipoprotein (LDL) apheresis reduces proteinuria and improves prognosis. However, its impact on patients’ quality of life (QoL) is unclear. This study evaluated the effect of LDL apheresis on QoL in patients with diabetes, proteinuria, and hypercholesterolemia.MethodsIn this nationwide multicenter prospective study, we enrolled 40 patients with diabetes. Inclusion criteria were proteinuria (defined as an albumin/creatinine ratio≥ 3 g/g), serum creatinine levels< 2 mg/dL, and serum LDL≥ 120 mg/dL despite drug treatment. LDL apheresis was performed 6–12 times within 12 weeks. The 36-item Short Form Health Survey (SF-36) was used to analyze QoL.ResultsThe study enrolled 35 patients (27 men and 8 women; mean age 58.9±11.9 years). A comparison of baseline SF-36 values with those at the end of the course of apheresis found an improvement in the mean physical component summary (37.9±11.4 vs. 40.6±10.5, p= 0.051) and a significant increase in the mean mental component summary (MCS)(49.4±8.4 vs. 52.5±10.9, p= 0.026). A multivariable linear regression analysis revealed a history of coronary heart disease negatively correlated with the MCS increase at the end of the course of apheresis (β coefficient− 6.935, 95% confidence interval, 13.313 to− 0.556, p= 0.034).ConclusionOur results suggest that LDL apheresis may improve the mental and physical QoL in patients with diabetes, proteinuria, and hypercholesterolemia.
