The Right Dorsal Premotor Mosaic: Organization, Functions, and Connectivity
The Right Dorsal Premotor Mosaic: Organization, Functions, and Connectivity
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DOI：
10.1093/cercor/bhw065
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发表时间：
2017-03-01
期刊：
影响因子：
3.7
通讯作者：
Eickhoff, Simon B.
中科院分区：
文献类型：
--
作者：
Genon, Sarah;Li, Hai;Eickhoff, Simon B.
人类右背侧运动前区皮质（PMd）参与了广泛的运动和认知功能。我们探索了这种行为异质性的基础上进行连接性为基础的parcellation元分析方法应用到PMD共激活。我们比较了我们的连接性为基础的包裹的结果，通过静息态功能连接和概率扩散纤维束成像获得的包裹。功能连接配置文件和行为解码的PMd子区域允许表征各自的行为配置文件。这些程序分为5个不同的亚区，形成了一个认知运动梯度沿着喙尾轴的右PMD。特别是，我们发现1）一个吻侧亚区与前额叶皮层功能连接，这可能支持高层次的认知过程，如工作记忆，2）一个中央亚区显示出混合的行为特征和功能连接到顶叶区的背侧注意网络，和3）一个尾侧亚区与运动系统紧密结合。此外，我们还发现了4）背侧亚区，优先与手部运动相关，并与认知和运动区域相连，以及5）腹侧亚区，其功能概况符合眼动相关领域的概念。因此，右PMd可以看作是由5个亚区组成的功能镶嵌体。
The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions. We explored the basis of this behavioral heterogeneity by performing a connectivity-based parcellation using metaanalytic approach applied to PMd coactivations. We compared our connectivity-based parcellation results with parcellations obtained through resting-state functional connectivity and probabilistic diffusion tractography. Functional connectivity profiles and behavioral decoding of the resulting PMd subregions allowed characterizing their respective behavior profile. These procedures divided the right PMd into 5 distinct subregions that formed a cognitive-motor gradient along a rostro-caudal axis. In particular, we found 1) a rostral subregion functionally connected with prefrontal cortex, which likely supports high-level cognitive processes, such as working memory, 2) a central subregion showing a mixed behavioral profile and functional connectivity to parietal regions of the dorsal attention network, and 3) a caudal subregion closely integrated with the motor system. Additionally, we found 4) a dorsal subregion, preferentially related to handmovements and connected to both cognitive and motor regions, and 5) a ventral subregion, whose functional profile fits the concept of an eye movement-related field. In conclusion, right PMd may be considered as a functional mosaic formed by 5 subregions.