Prevalence and Outcomes of Frailty in Korean Elderly Population: Comparisons of a Multidimensional Frailty Index with Two Phenotype Models
Prevalence and Outcomes of Frailty in Korean Elderly Population: Comparisons of a Multidimensional Frailty Index with Two Phenotype Models
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DOI：
10.1371/journal.pone.0087958
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发表时间：
2014-02-04
期刊：
影响因子：
3.7
通讯作者：
Kim, Cheol-Ho
中科院分区：
文献类型：
--
作者：
Jung, Hee-Won;Kim, Sun-Wook;Kim, Cheol-Ho
背景：虚弱与老年人的不良后果有关。然而，韩国老年人群虚弱的现状和临床意义尚未得到评估。我们的目的是调查为居住在社区的韩国老年人制定的衰弱标准的有用性。我们还尝试开发和验证基于多维模型的新虚弱指数。方法：我们研究了韩国健康与老龄化纵向研究 (KLoSHA) 的 693 名参与者。我们开发了一种新的衰弱指数（KLoSHA 衰弱指数，KFI），并将其可预测性与心血管健康研究（CHS）和骨质疏松性骨折研究（SOF）中已建立的衰弱指数进行了比较。对死亡率、住院治疗和功能衰退进行了评估。结果：虚弱患病率为 9.2%（SOF 指数）、13.2%（CHS 指数）和 15.6%（KFI）。 CHS 和 KFI 的标准相互相关，但 SOF 与 KFI 不相关。在随访期间（5.6 +/- 0.9 年），97 名参与者（14.0%）死亡。 KFI 定义的衰弱比 CHS 指数更好地预测死亡率（c 指数：分别为 0.713 和 0.596；p
Background: Frailty is related to adverse outcomes in the elderly. However, current status and clinical significance of frailty have not been evaluated for the Korean elderly population. We aimed to investigate the usefulness of established frailty criteria for community-dwelling Korean elderly. We also tried to develop and validate a new frailty index based on a multidimensional model.Methods: We studied 693 participants of the Korean Longitudinal Study on Health and Aging (KLoSHA). We developed a new frailty index (KLoSHA Frailty Index, KFI) and compared predictability of it with the established frailty indexes from the Cardiovascular Health Study (CHS) and Study of Osteoporotic Fracture (SOF). Mortality, hospitalization, and functional decline were evaluated.Results: The prevalence of frailty was 9.2% (SOF index), 13.2% (CHS index), and 15.6% (KFI). The criteria from CHS and KFI correlated with each other, but SOF did not correlate with KFI. During the follow-up period (5.6 +/- 0.9 years), 97 participants (14.0%) died. Frailty defined by KFI predicted mortality better than CHS index (c-index: 0.713 and 0.596, respectively; p