Somatotopic organization in the internal segment of the globus pallidus in Parkinson's disease
Somatotopic organization in the internal segment of the globus pallidus in Parkinson's disease
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DOI：
10.1016/j.expneurol.2009.12.030
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发表时间：
2010-04-01
影响因子：
5.3
通讯作者：
Vitek, Jerrold L.
中科院分区：
文献类型：
--
作者：
Baker, Kenneth B.;Lee, John Y. K.;Vitek, Jerrold L.
苍白球内段消融或脑深部刺激(GP(1))是治疗帕金森病(PD)的有效方法，但许多患者仅获得部分益处，包括不同身体区域的不同程度改善，这可能与Gilt手术对不同身体区域的不同效果有关。不幸的是。我们对人类GP(1)的体位组织的理解是基于有限样本量的少量研究，包括仅基于单一记录轨道或平面的几项研究。以全面解决GP的三维体位组织(1)。我们在一大群接受立体定向手术的患者中检测了苍白球神经元的感受野特性。用至少三个横跨至少两个内-外侧平面的轨迹来确定神经元对肢体和口面部结构主动和被动运动的反应，并对299名患者的3183个神经元进行了评估。其中1972个(62%)受感觉运动调控，1767个反应于单个对侧躯体区域，其余205个反应于多个和/或同侧躯体区域，腿相关神经元位于手臂相关神经元的背侧、内侧和前部。虽然手臂相关神经元位于口面部相关神经元的背侧，但这项研究提供了更详细的个体身体区域以及每个区域内特定关节的地图，并为接受运动障碍手术治疗的患者的GP(1)病变或DBS对身体不同部位的不同影响提供了潜在的解释(C)2010 Elsevier Inc.保留所有权利。
Ablation or deep brain stimulation in the internal segment of the globus pallidus (GP(1)) is an effective therapy for the treatment of Parkinson's disease (PD) Yet many patients receive only partial benefit, including varying levels of improvement across different body regions, which may relate to a differential effect of Gilt surgery on the different body regions. Unfortunately. our understanding of the somatotopic organization of human GP(1) is based on a small number of studies with limited sample sizes, Including several based upon only a single recording track or plane. To fully address the three-dimensional somatotopic organization of GP(1). we examined the receptive field properties of pallidal neurons in a large cohort of patients undergoing stereotactic Surgery The response of neurons to active and passive movements of the limbs and orofacial Structures was determined, using a minimum of three tracks across at least two medial-lateral planes Neurons (3183) were evaluated from 299 patients. of which 1972 (62%) were modulated by sensorimotor manipulation Of these, 1767 responded to a single, contralateral body region, with the remaining 205 responding to multiple and/or ipsilateral body regions Leg-related neurons were found dorsal, medial and anterior to arm-related neurons. while arm-related neurons were dorsal and lateral to orofacial-related neurons This study provides a more detailed map of individual body regions as well as specific joints within each region and provides a potential explanation for the differential effect of lesions or DBS of the GP(1) on different body parts in patients undergoing surgical treatment of movement disorders (C) 2010 Elsevier Inc All rights reserved.