Impact of Mediterranean diet on metabolic syndrome, cancer and longevity.
Impact of Mediterranean diet on metabolic syndrome, cancer and longevity.
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DOI：
10.18632/oncotarget.13553
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发表时间：
2017-01-31
期刊：
影响因子：
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通讯作者：
De Lorenzo A
中科院分区：
文献类型：
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作者：
Di Daniele N;Noce A;Vidiri MF;Moriconi E;Marrone G;Annicchiarico-Petruzzelli M;D'Urso G;Tesauro M;Rovella V;De Lorenzo A
肥胖是一个重大的公共健康问题。超重和肥胖与代谢综合征的发生和脂肪组织功能障碍有关。脂肪组织是代谢活跃的内分泌器官，其失调导致低度炎症状态和异位脂肪沉积。地中海饮食代表了一种可能的治疗代谢综合征，防止脂肪病或“病态脂肪”的形成。地中海饮食对有和无基线慢性病的老年受试者都有保护作用。最近的研究表明癌症和肥胖之间存在联系。在美国，饮食占癌症相关死亡原因的30-35%。目前，癌症是全球仅次于心血管疾病的第二大死亡原因。此外，与生活在北方或美国的人群相比，生活在地中海地区的人群癌症发病率降低，这可能是由于更健康的饮食习惯。生物活性食品成分对癌症具有潜在的预防作用。本综述的目的是评估地中海饮食对代谢综合征、癌症和长寿的发病、进展和消退的影响。
Obesity symbolizes a major public health problem. Overweight and obesity are associated to the occurrence of the metabolic syndrome and to adipose tissue dysfunction. The adipose tissue is metabolically active and an endocrine organ, whose dysregulation causes a low-grade inflammatory state and ectopic fat depositions. The Mediterranean Diet represents a possible therapy for metabolic syndrome, preventing adiposopathy or “sick fat” formation. The Mediterranean Diet exerts protective effects in elderly subjects with and without baseline of chronic diseases. Recent studies have demonstrated a relationship between cancer and obesity. In the US, diet represents amount 30-35% of death causes related to cancer. Currently, the cancer is the second cause of death after cardiovascular diseases worldwide. Furthermore, populations living in the Mediterranean area have a decreased incidence of cancer compared with populations living in Northern Europe or the US, likely due to healthier dietary habits. The bioactive food components have a potential preventive action on cancer. The aims of this review are to evaluate the impact of Mediterranean Diet on onset, progression and regression of metabolic syndrome, cancer and on longevity.
影响因子：
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作者：
Ned RM;Yesupriya A;Imperatore G;Smelser DT;Moonesinghe R;Chang MH;Dowling NF
通讯作者：
Dowling NF