Thiol modification by bioactivated polyphenols and its potential role in skin inflammation.
Thiol modification by bioactivated polyphenols and its potential role in skin inflammation.
复制标题
生物活性多酚的硫醇修饰及其在皮肤炎症中的潜在作用。
DOI：
10.1080/09168451.2014.905190
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Murata Y.
中科院分区：
文献类型：
--
作者：
Nakamura Y;Ishii T;Abe N;Murata Y.
在本研究中，我们评估了简单的酚类化合物对谷胱甘肽和蛋白质巯基的修饰行为。儿茶酚型多酚，包括原儿茶酸，但无论是单酚或O-甲基化的儿茶酚，可以修饰巯基的酚氧化酶依赖性的方式。多酚生物活化可能参与皮肤炎症的增强。
In the present study, we evaluated the modifying behavior of simple phenolic compounds on the sulfhydryl groups of glutathione and proteins. The catechol-type polyphenols, including protocatechuic acid, but neither the monophenols norO-methylated catechol, can modify the sulfhydryl groups in a phenol oxidase-dependent manner. The possible involvement of polyphenol bioactivation in the enhancement of skin inflammation was also suggested.