Sequence sensitivity of neurons in cat primary auditory cortex
Sequence sensitivity of neurons in cat primary auditory cortex
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DOI：
10.1093/cercor/10.12.1155
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发表时间：
2000-12-01
期刊：
影响因子：
3.7
通讯作者：
Schreiner, CE
中科院分区：
文献类型：
--
作者：
Brosch, M;Schreiner, CE
对猫初级听皮层序列敏感神经元的特性进行了详细的研究。刺激序列的两个音调，其中的频率和强度的第一个音调和第一和第二，或探针，音调之间的时间间隔参数变化。在呈现第一个音调后，发现32个单单位和48个多单位对探测音的反应比在单音条件下获得的反应增强了140-5270%（中位数340%）。探测音增强是由相当数量的序列条件引起的，并且取决于第一个音调的频率和强度以及第一个和探测音的起始之间的时间间隔。平均而言，当第一个音低于或高于探测音1个八度并且其强度比探测音大14 dB时，发生最大增强反应。增强效果的音调的最有效的时间间隔是类似于100毫秒。增强音调的范围在很大程度上是神经元的兴奋性调谐曲线之外。结果扩展了先前的研究结果的序列敏感神经元的回声定位蝙蝠和非回声定位哺乳动物的听觉皮层的属性，并建议序列敏感神经元是相当普遍的，并参与皮质表示的声信号的spectrotemporal模式。
Properties of sequence sensitive neurons in primary auditory cortex of cats were explored in detail. Stimuli were sequences of two tones, in which the frequency and intensity of the first tone and the temporal separation between the first and second, or probe, tone were parametrically varied. After presentation of the first tone, the responses of 32 single units and 48 multiunits to the probe tone were found to be enhanced up to 140-5270% (median 340%) above the response obtained in the single-tone condition. Probe tone enhancement was induced from a considerable number of sequence conditions and depended on the frequency and intensity of the first tone and on the temporal separation between the onsets of the first and the probe tone. On average, the maximally enhanced response occurred when the first tone was 1 octave below or above the probe tone and its intensity was 14 dB louder than the probe tone. The most effective temporal separation of the tones for an enhancement effect was similar to 100 ms. The range of enhancing tones was largely outside the excitatory tuning curve of a neuron. Results extend previous findings of properties of sequence-sensitive neurons in the auditory cortex of echolocating bats and non-echolocating mammals, and suggest that sequence-sensitive neurons are quite common and involved in the cortical representation of spectrotemporal patterns of acoustic signals.