Total Synthesis of Pseudouridimycin and Its Epimer via Ugi-type Multicomponent Reaction
Total Synthesis of Pseudouridimycin and Its Epimer via Ugi-type Multicomponent Reaction
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Ugi型多组分反应全合成伪尿嘧啶及其差向异构体
DOI：
10.1039/d2cc02442j
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Satoshi Ichikawa
中科院分区：
文献类型：
--
作者：
Ryotaro Okawa;Courtney C. Aldrich;Satoshi Ichikawa
完成了假尿嘧啶霉素（1）的全合成，其特征在于一种不寻常的肟Ugi型多组分缩合，以同时构建这种肽基核苷抗生素的二肽部分。在该合成路线中，1容易通过由假尿苷开始的9个合成步骤的最长线性序列获得。该策略可适用于多种假尿嘧啶霉素类似物。
A total synthesis of pseudouridimycin (1) was accomplished featuring an unusual oxime Ugi-type multicomponent condensation to simultaneously construct the dipeptide moiety of this peptidyl nucleoside antibiotic. In this synthetic route 1 is readily accessible via a longest linear sequence of 9 synthetic steps from pseudouridine. This strategy can be applicable to a variety of pseudouridimycin analogues.