Roles of microRNA on cancer cell metabolism.
Roles of microRNA on cancer cell metabolism.
复制标题
microRNA对癌细胞代谢的作用
DOI：
10.1186/1479-5876-10-228
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发表时间：
2012-11-20
影响因子：
7.4
通讯作者：
Liang S
中科院分区：
文献类型：
--
作者：
Chen B;Li H;Zeng X;Yang P;Liu X;Zhao X;Liang S
对microRNAs （miRNAs）的深入研究揭示了其多种生物学功能，包括控制细胞增殖、细胞周期和细胞死亡。然而，近年来，它们作为代谢的关键调节因子的作用越来越受到人们的关注。与未转化的细胞相比，癌细胞表现出更高的代谢自主性，吸收营养物质并在支持生长和增殖的途径中代谢它们。mirna通过复杂的机制调控细胞代谢过程，包括直接靶向代谢过程的关键酶或转运体，调控转录因子、癌基因/肿瘤抑制因子以及多种致癌信号通路。miR-375、miR-143、miR-14、miR-29b等mirna通过调控基因的表达参与癌细胞代谢的调控，这些基因的蛋白产物或直接调控代谢机制，或间接调控代谢酶的表达，作为主调控因子，有望为恶性肿瘤的治疗提供新的策略。本文综述了miRNA对癌细胞代谢的调控，包括葡萄糖摄取、糖酵解、三羧酸循环和胰岛素产生、脂质代谢和氨基酸生物发生，以及几种致癌信号通路。此外，本文还讨论了基于mirna的癌症诊断、预后和治疗策略所面临的挑战。
Advanced studies of microRNAs (miRNAs) have revealed their manifold biological functions, including control of cell proliferation, cell cycle and cell death. However, it seems that their roles as key regulators of metabolism have drawn more and more attention in the recent years. Cancer cells display increased metabolic autonomy in comparison to non-transformed cells, taking up nutrients and metabolizing them in pathways that support growth and proliferation. MiRNAs regulate cell metabolic processes through complicated mechanisms, including directly targeting key enzymes or transporters of metabolic processes and regulating transcription factors, oncogenes / tumor suppressors as well as multiple oncogenic signaling pathways. MiRNAs like miR-375, miR-143, miR-14 and miR-29b participate in controlling cancer cell metabolism by regulating the expression of genes whose protein products either directly regulate metabolic machinery or indirectly modulate the expression of metabolic enzymes, serving as master regulators, which will hopefully lead to a new therapeutic strategy for malignant cancer. This review focuses on miRNA regulations of cancer cell metabolism,including glucose uptake, glycolysis, tricarboxylic acid cycle and insulin production, lipid metabolism and amino acid biogenesis, as well as several oncogenic signaling pathways. Furthermore, the challenges of miRNA-based strategies for cancer diagnosis, prognosis and therapeutics have been discussed.
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影响因子：
30.8
作者：
Bourdon, Alice;Minai, Limor;Rotig, Agnes
通讯作者：
Rotig, Agnes
影响因子：
11.2
作者：
Bader AG;Brown D;Winkler M
通讯作者：
Winkler M
DOI：
10.1073/pnas.0800121105
发表时间：
2008-04-01
影响因子：
11.1
作者：
Calin, George A.;Cimmino, Amelia;Croce, Carlo M.
通讯作者：
Croce, Carlo M.
影响因子：
3.3
作者：
Edinger, AL;Thompson, CB
通讯作者：
Thompson, CB
影响因子：
7.7
作者：
El Ouaamari A;Baroukh N;Martens GA;Lebrun P;Pipeleers D;van Obberghen E
通讯作者：
van Obberghen E