Pancreatitis in childhood.
Pancreatitis in childhood.
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DOI：
10.1007/s11894-004-0014-5
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发表时间：
2004-06-01
影响因子：
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通讯作者：
Lowe, Mark E
中科院分区：
文献类型：
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作者：
Lowe, Mark E
胰腺的炎症性疾病福尔斯分为两大类：急性和慢性。急性胰腺炎是一个可逆的过程，而慢性胰腺炎产生胰腺结构和功能的不可逆变化。最近发现编码阳离子胰蛋白酶原的基因突变与遗传性胰腺炎有关，发现了增加慢性胰腺炎风险的基因，以及细胞生物学的进展，极大地促进了我们对导致胰腺炎的分子机制的理解。虽然胰腺炎在儿童中不像成人那么常见，但它仍然有规律地发生，并且应该考虑任何急性或慢性腹痛的儿童。儿童和成人胰腺炎的主要区别在于急性胰腺炎的病因和结局以及慢性胰腺炎的病因。急性和慢性胰腺炎的治疗在所有年龄段都是相似的。
Inflammatory disease of the pancreas falls into two major classifications: acute and chronic. Acute pancreatitis is a reversible process, whereas chronic pancreatitis produces irreversible changes in the architecture and function of the pancreas. The recent finding that mutations in the gene encoding cationic trypsinogen are associated with hereditary pancreatitis, the identification of genes that increase the risk for developing chronic pancreatitis, and advances in cell biology have contributed greatly to our understanding of the molecular mechanisms leading to pancreatitis. Although pancreatitis is less common in children than in adults, it still occurs with regularity and should be considered in any child with acute or chronic abdominal pain. The major difference between pancreatitis in children and adults lies in the etiologies and outcome of acute pancreatitis and in the etiology of chronic pancreatitis. The treatment of acute and chronic pancreatitis is similar at all ages.