Prevention of pit and fissure caries using an antimicrobial varnish: 9 month clinical evaluation
Prevention of pit and fissure caries using an antimicrobial varnish: 9 month clinical evaluation
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DOI：
10.1016/s0300-5712(00)00060-9
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发表时间：
2001-05-01
影响因子：
4.4
通讯作者：
Adenubi, JO
中科院分区：
文献类型：
--
作者：
Joharji, RM;Adenubi, JO
目的：研究氯己定涂膜Cervitec能否减少儿童窝沟龋病的发生。方法：从沙特阿拉伯利雅得的学校中抽取100名7~8岁和12~14岁的儿童。要被纳入这项研究，每个孩子必须至少有两颗健全的对侧第一或第二恒磨牙，并有深深的裂隙。一颗实验牙和一颗对照牙在同一个颌骨内，采用张开嘴法。随机选择左侧或右侧进行测试或对照。用Jensen和Bratthall(Jensen B，Bratthall D)的变形链球菌条带法测定唾液中变形链球菌的数量。牙科研究杂志1989：68：468-471)。在隔离后的基线、3-4个月和6个月分别使用含1%洗必泰(ChX)和百里香酚的Cervitec清漆，而对照组每次在测试牙齿上涂抹清漆时都用水中的棉球进行预防。根据WHO(世界卫生组织)的标准和方法，在9个月后进行龋病检查和对照。口腔健康调查。《基本方法》第四版，日内瓦，世界卫生组织，1997年)。结果：7~8岁儿童94人，12~14岁儿童86人。结果表明，9个月后，两组对照牙的龋病增量均显著高于试验牙(McNemar检验：X_1(2)=11.60，P<；0.001)。窝沟患龋率与菌斑变形菌斑评分呈显著正相关，试验牙菌斑变形链球菌计数较对照牙菌斑明显减少(Spearman等级相关：P<；0.001)。结论：CHX涂膜显著抑制了窝沟龋病的发生。(C)2001爱思唯尔科学有限公司。保留所有权利。
Objective: The purpose of this study was to determine whether Cervitec-a chlorhexidine-containing varnish could reduce the development of pit and fissure caries in children.Methods: One hundred children each in age groups 7-8 and 12-14 years were selected from schools in Riyadh, Saudi Arabia. To be included in the study, each child had to have at least two sound contra-lateral first or second permanent molars with deep fissures. A split mouth method was used with one test tooth and one control within the same jaw. The left or the right side was selected randomly for test or control. The plaque samples from the occlusal surfaces of the test and control and the saliva samples were collected at baseline examination and after 9 months to estimate the number of Streptococcus mutans by the strip mutans method of Jensen and Bratthall (Jensen B, Bratthall D. A new method for the estimation of mutans streptococci in human saliva. Journal of Dental Research 1989:68:468-471).Cervitec varnish containing 1% chlorhexidine (CHx) and thymol was applied at baseline, at 3-4 months and at 6 months to the test tooth after isolation while the control had prophylaxis using cotton pellet in water each time the varnish was applied to the test tooth. Caries examination of the test and control followed after 9 months, according to the criteria and methods of WHO (World Health Organization. Oral Health Surveys. Basic Methods 4th ed., Geneva, WHO 1997). The blind technique was used in the diagnosis of caries and in the examination of the S. mutans count at the end of the study.Results: Ninety four of the 7-8 year old and 86 of the 12-14 year old children completed the study. The results showed that the caries increment in both control groups of teeth after 9 months is significantly higher than in the test teeth (McNemar test: chi (2) = 11.60, P < 0.001). The rate of caries development in a fissure was significantly correlated to the plaque mutans score of that fissure and there was considerable reduction in the S. mutans count of the plaque in the test teeth compared with the control (Spearman Rank Correlation: P < 0.001).Conclusion: It is concluded that the CHx varnish reduced the development of fissure caries significantly. (C) 2001 Elsevier Science Ltd. All rights reserved.