Neutrophils are required for 3-methylcholanthrene-initiated, butylated hydroxytoluene-promoted lung carcinogenesis.
Neutrophils are required for 3-methylcholanthrene-initiated, butylated hydroxytoluene-promoted lung carcinogenesis.
复制标题
中性粒细胞是 3-甲基胆蒽引发、丁基羟基甲苯促进的肺癌发生所必需的。
DOI：
10.1002/mc.20870
复制
发表时间：
2012-12
影响因子：
4.6
通讯作者：
You, Ming
中科院分区：
文献类型：
--
作者：
Vikis, Haris G.;Gelman, Andrew E.;Franklin, Andrew;Stein, Lauren;Rymaszewski, Amy;Zhu, Jihong;Liu, Pengyuan;Tichelaar, Jay W.;Krupnick, Alexander S.;You, Ming
多项研究表明，慢性炎症与肺部肿瘤发生之间存在联系。近交系小鼠对甲基胆蒽(MCA)引发的丁基羟基甲苯(BHT)促进的肺癌的敏感性不同。在目前的研究中，我们调查了中性粒细胞是否在菌株依赖的肺癌易感性差异中发挥了作用。我们观察到肿瘤易感的BALB/cByJ(BALB)小鼠肺中中性粒细胞的稳态水平显著高于肿瘤耐药的C57BL/6J(B6)小鼠。此外，BHT治疗进一步增加了BALB肺气道中性粒细胞数量以及中性粒细胞趋化因子角质形成细胞衍生细胞因子(KC)/趋化因子(C-X-C基序)配体1(CXCL1)的水平。肺CD11c+细胞是BALB小鼠KC表达的主要来源，中性粒细胞的耗竭导致肿瘤多样性下降71%。然而，肿瘤的多样性并不依赖于T细胞的存在，尽管BHT治疗后T细胞积聚。这些数据表明，在MCA/BHT两步肺癌模型中，中性粒细胞对促进肿瘤生长是必不可少的。
Multiple studies have shown a link between chronic inflammation and lung tumorigenesis. Inbred mouse strains vary in their susceptibility to methylcholanthrene (MCA)-initiated butylated hydroxytoluene (BHT)-promoted lung carcinogenesis. In the present study we investigated whether neutrophils play a role in strain dependent differences in susceptibility to lung tumor promotion. We observed a significant elevation in homeostatic levels of neutrophils in the lungs of tumor-susceptible BALB/cByJ (BALB) mice compared to tumor-resistant C57BL/6J (B6) mice. Additionally, BHT treatment further elevated neutrophil numbers as well as neutrophil chemoattractant keratinocyte-derived cytokine (KC)/chemokine (C-X-C motif) ligand 1 (Cxcl1) levels in BALB lung airways. Lung CD11c+ cells were a major source of KC expression and depletion of neutrophils in BALB mice resulted in a 71% decrease in tumor multiplicity. However, tumor multiplicity did not depend on the presence of T cells, despite the accumulation of T cells following BHT treatment. These data demonstrate that neutrophils are essential to promote tumor growth in the MCA/BHT two-step lung carcinogenesis model.
登录
查看更多内容
影响因子：
4.4
作者：
Keane, MP;Belperio, JA;Strieter, RM
通讯作者：
Strieter, RM
影响因子：
2.7
作者：
Gungor, Nejla;Haegens, Astrid;van Schooten, Frederik J.
通讯作者：
van Schooten, Frederik J.
影响因子：
8
作者：
Ji, H;Houghton, AM;Wong, KK
通讯作者：
Wong, KK
影响因子：
4.5
作者：
Bauer, AK;Dwyer-Nield, LD;Malkinson, AM
通讯作者：
Malkinson, AM
影响因子：
4.8
作者：
Gungor, Nejla;Godschalk, Roger W. L.;Knaapen, Ad M.
通讯作者：
Knaapen, Ad M.