A quantification of the lung surface area in emphysema using computed tomography
A quantification of the lung surface area in emphysema using computed tomography
复制标题
DOI：
10.1164/ajrccm.159.3.9805067
复制
发表时间：
1999-03-01
影响因子：
24.7
通讯作者：
Hogg, JC
中科院分区：
文献类型：
--
作者：
Coxson, HO;Rogers, RM;Hogg, JC
计算机断层扫描（CT）的定量分析已与基于体视学的肺结构组织学分析相结合，以评估局部肺膨胀和肺实质的结构特征。在这项研究中，肺膨胀的CT测量值与表面积的组织学估计值进行了比较，以开发预测方程，使肺表面积与体积比和表面积从CT扫描的分析进行预测。结果表明，轻度肺气肿与肺体积的增加和表面积与体积比的减少有关，而表面积和组织重量仅在严重疾病中减少。CT预测的表面积与体积比与组织学相关，预测和测量的表面积与弥散能力相关。我们的结论是，这种CT分析可用于监测肺气肿肺破坏的进展，在个别患者，并评估肺气肿的手术和药物治疗的影响。
Quantitative analysis of computed tomography (CT) has been combined with a stereologically based histologic analysis of lung structure to assess regional lung inflation and the structural features of the lung parenchyma. In this study, CT measurements of lung inflation were compared with histologic estimates of surface area in order to develop prediction equations that allow lung surface to volume ratio and surface area to be predicted from an analysis of the CT scan. The results show that mild emphysema is associated with an increase in lung volume and a reduction in surface to volume ratio, whereas surface area and tissue weight were only decreased in severe disease. The CT predicted surface to volume ratio correlated with histology, and both predicted and measured surface areas correlated with the diffusing capacity. We conclude that this CT analysis can be used to monitor the progression of emphysematous lung destruction in individual patients, and to assess the impact of both surgical and medical treatments for emphysema.