Prolactin-induced parental hyperphagia in ring doves: are glucocorticoids involved?
Prolactin-induced parental hyperphagia in ring doves: are glucocorticoids involved?
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DOI：
10.1016/j.yhbeh.2004.02.012
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发表时间：
2004-11-01
影响因子：
3.5
通讯作者：
Buntin, JD
中科院分区：
文献类型：
--
作者：
Koch, KA;Wingfield, JC;Buntin, JD
摄食过多是雄性和雌性环鸽的父母行为的一个重要组成部分，并且是父母成功地提供他们成长中的年轻人所必需的。虽然以前的研究涉及催乳素和内源性糖皮质激素，皮质酮，在父母的摄食过多，这两种激素之间的功能相互作用，在调节摄食活动的变化还没有被表征。这些研究检查了催乳素的食欲促进作用是通过增加皮质酮分泌来介导的可能性。每日两次侧脑室注射催乳素，可增加非繁殖性别鸽子的血浆皮质酮浓度，雄性比雌性效果更明显。为了进一步测试糖皮质激素信号传导在催乳素诱导的进食反应中的重要性，在icv输注糖皮质激素受体拮抗剂RU 38486或丙二醇媒介物后，在icv催乳素处理的非繁殖鸽子中研究食物摄入的变化。在以先前显示的阻断地塞米松诱导的鸽子摄食的剂量共同给予RU 38486后，在任一性别中均未观察到催乳素诱导的摄食过多减弱。这些研究结果表明，血中皮质酮滴度升高可能有助于观察到的食欲过旺，催乳素的反应，但皮质酮信号通过一个cardialian型糖皮质激素受体是不必要的。(C)2004年爱思唯尔公司All rights reserved.
Hyperphagia is a prominent component of the parental behavior repertoire in male and female ring doves and is necessary in order for parents to successfully provision their growing young. Although previous studies implicate both prolactin and the endogenous glucocorticoid, corticosterone, in parental hyperphagia, the functional interactions between these two hormones in regulating changes in feeding activity have not been characterized. These studies examined the possibility that prolactin's orexigenic effects are mediated through the increased secretion of corticosterone. Twice-daily intracerebroventricular (icv) injection of prolactin increased plasma corticosterone concentration in non-breeding doves of both sexes, with males exhibiting more pronounced effects than females. To further test the importance of glucocorticoid signaling in prolactin-induced feeding responses, changes in food intake were investigated in icv prolactin-treated, non-breeding doves following icv infusion of the glucocorticoid receptor antagonist RU38486 or propylene glycol vehicle. No attenuation of prolactin-induced hyperphagia was observed in either sex following co-administration of RU38486 at a dose shown previously to block dexamethasone-induced feeding in doves. These findings suggest that elevated corticosterone titers in blood may contribute to the hyperphagia observed in response to prolactin, but corticosterone signaling through a mammalian-type glucocorticoid receptor is not essential. (C) 2004 Elsevier Inc. All rights reserved.