Use of simulated epithelial lung fluid in assessing the human health risk of Pb in urban street dust
Use of simulated epithelial lung fluid in assessing the human health risk of Pb in urban street dust
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DOI：
10.1016/j.scitotenv.2016.11.085
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发表时间：
2017-02-01
影响因子：
9.8
通讯作者：
Entwistle, Jane A.
中科院分区：
文献类型：
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作者：
Dean, John R.;Elom, Nwabueze I.;Entwistle, Jane A.
在许多城市环境中，来自街道灰尘的非膳食铅暴露可能会增加总体暴露负担，并且地球仪的城市街道灰尘中存在高总铅含量。鉴于越来越多的人认识到吸入部分的数量以及化学和物理成分对健康的潜在不利影响，以及认识到可溶性部分而不是总元素含量与健康影响有更直接的联系，本研究的注意力集中在通过这种暴露途径对人类健康的风险上。为了研究城市街道灰尘对铅的环境暴露，采用体外模拟上皮细胞肺液（SELF），
In many urban contexts, non-dietary Pb exposure from street dusts may add to the overall exposure burden, and the presence of high total Pb content is well documented in urban street dust from across the globe. Given the increasing recognition of the potential adverse health effects from both the quantity and the chemical and physical composition of the inhaled fraction, and the recognition that it is the soluble fraction rather than the total element content that has more direct links to health effects, attention has focused in this study on the human health risks via this exposure pathway. In order to investigate the environmental exposure to Pb from the inhalation of urban street dusts, a newly developed in vitro simulated epithelium lung fluid (SELF) has been applied to the