The effects of daily chlorhexidine bathing on cutaneous bacterial isolates: a pilot study.
The effects of daily chlorhexidine bathing on cutaneous bacterial isolates: a pilot study.
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DOI：
10.2147/idr.s30662
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发表时间：
2012
影响因子：
3.9
通讯作者：
Zerr DM
中科院分区：
文献类型：
--
作者：
Soma VL;Qin X;Zhou C;Adler A;Berry JE;Zerr DM
葡萄糖酸氯己定（CHG）是一种局部抗菌剂，用于无数的临床设置。最近，CHG浴已被证明可以减少多药耐药菌获得和感染以及导管相关血流感染。本研究探讨了每天用CHG沐浴对皮肤可培养细菌的恢复和抗菌敏感性的影响。本研究的目的是：(1)探讨临床CHG沐浴对可培养皮肤细菌的影响，(2)研究CHG最低抑制浓度与凝固酶阴性葡萄球菌抗菌敏感性之间的关系，以及(3)证明该方法的可行性，以便进行更明确的研究。随着CHG暴露的增加，细菌菌落计数和表型多样性显著减少。研究结果还表明，CHG最低抑菌浓度与抗菌药物敏感性呈反比关系。需要更大规模的前瞻性研究来充分调查使用CHG的临床影响。
Chlorhexidine gluconate (CHG) is a topical antiseptic used in a myriad of clinical settings. Recently, CHG baths have been shown to decrease multidrug-resistant organism acquisition and infections and catheter-associated bloodstream infections. The present study examined the effects of daily bathing with CHG on the recovery and antimicrobial susceptibility of cultivable cutaneous bacteria. The objectives of this study were to (1) explore the effects of clinical CHG bathing on cultivable cutaneous bacteria, (2) study the relationship between CHG minimum inhibitory concentration and antimicrobial susceptibility of coagulase-negative staphylococci, and (3) demonstrate the feasibility of the approach so a more definitive study may be performed. Significant decreases in bacterial colony counts and phenotypic diversity occurred with greater CHG exposure. The findings also suggest an inverse relationship between CHG minimum inhibitory concentration and antimicrobial susceptibility. Larger prospective studies are necessary to fully investigate the clinical impact of CHG usage.