Ulcerative colitis
Ulcerative colitis
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DOI：
10.1016/s0140-6736(12)60150-0
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发表时间：
2012-11-03
期刊：
影响因子：
168.9
通讯作者：
Sandborn, William J.
中科院分区：
文献类型：
--
作者：
Ordas, Ingrid;Eckmann, Lars;Sandborn, William J.
溃疡性结肠炎是一种结肠粘膜的特发性慢性炎症性疾病，始于直肠，通常以连续的方式向近端延伸，穿过部分或整个结肠；然而，一些患有直肠炎或左侧结肠炎的患者可能有盲肠炎症斑块。带血腹泻是该病的特征性症状。临床过程是不可预测的，其特点是交替发作和缓解。在本次研讨会中，我们将讨论溃疡性结肠炎的流行病学、病理生理学、诊断方法、自然史、内科和外科治疗以及主要疾病相关并发症，并简要概述新的治疗方案。对环境因素、遗传和免疫系统之间的相互作用如何导致粘膜炎症的理解增强了对疾病病理生理学的认识。我们提供易于应用于日常临床实践的实用治疗算法，强调目前在治疗管理和新疗法方面的争议。
Ulcerative colitis is an idiopathic, chronic inflammatory disorder of the colonic mucosa, which starts in the rectum and generally extends proximally in a continuous manner through part of, or the entire, colon; however, some patients with proctitis or left-sided colitis might have a caecal patch of inflammation. Bloody diarrhoea is the characteristic symptom of the disease. The clinical course is unpredictable, marked by alternating periods of exacerbation and remission. In this Seminar we discuss the epidemiology, pathophysiology, diagnostic approach, natural history, medical and surgical management, and main disease-related complications of ulcerative colitis, and briefly outline novel treatment options. Enhanced understanding of how the interaction between environmental factors, genetics, and the immune system results in mucosal inflammation has increased knowledge of disease pathophysiology. We provide practical therapeutic algorithms that are easily applicable in daily clinical practice, emphasising present controversies in treatment management and novel therapies.