Hematology and serum chemistry parameters in juvenile cynomolgus monkeys (Macaca fascicularis) of Mauritius origin: comparison between purpose-bred and captured animals
Hematology and serum chemistry parameters in juvenile cynomolgus monkeys (Macaca fascicularis) of Mauritius origin: comparison between purpose-bred and captured animals
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DOI：
10.1111/j.1600-0684.2009.00345.x
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发表时间：
2009-08-01
影响因子：
0.7
通讯作者：
Bernardi, Claudio
中科院分区：
文献类型：
--
作者：
Bonfanti, Ugo;Lamparelli, Domenica;Bernardi, Claudio
绝大多数用于实验活动的非人灵长类动物都是有目的地繁殖的。然而，在特殊程序或特定项目的情况下，可能仍有必要使用野外捕获的动物。方法根据繁殖来源随机选择60只食蟹猴，分为两组，每组15只雄性和15只雌性。分析包括最常见的血液学，凝血和生化参数。结果差异观察到一些参数，特别是在嗜酸性粒细胞，嗜碱性粒细胞和单核细胞，纤维蛋白原，总蛋白，球蛋白，丙氨酸氨基转移酶，肌酐，天冬氨酸氨基转移酶，碱性磷酸酶，γ-谷氨酰转移酶，乳酸脱氢酶，α-羟基丁酸脱氢酶，铁，钾，结论食蟹猴的某些值可能因动物的饲养背景而存在显著差异。只有从相似来源的动物中获得的数据才必须进行比较，以避免在评价实验结果时产生误解。
BackgroundThe vast majority of non-human primates used for experimental activities are purpose-bred. However, in case of particular procedures or specific projects, it may still be necessary to use animals captured in the wild.MethodsSixty cynomolgus monkeys were randomly selected on the basis of breeding origin, and assigned to two groups, each of fifteen males and fifteen females. Analyses included the most frequently investigated parameters for hematology, coagulation, and biochemistry.ResultsDifferences were observed in some parameters, particularly in eosinophils, basophils and monocytes, and in fibrinogen, total protein, globulins, alanine amino-transferase, creatinine, aspartate amino-transferase, alkaline phosphatase, gamma-glutamyl transferase, lactate dehydrogenase, alpha-hydroxybutyrate dehydrogenase, iron, potassium, and phosphorus.ConclusionsSome values in the cynomolgus monkey may show significant differences according to the breeding background of the animals. Only data obtained from animals of similar origin have to be compared, to avoid misinterpretation during the evaluation of the experimental results.