Dissociable neural systems resolve conflict from emotional versus nonemotional distracters
Dissociable neural systems resolve conflict from emotional versus nonemotional distracters
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DOI：
10.1093/cercor/bhm179
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发表时间：
2008-06-01
期刊：
影响因子：
3.7
通讯作者：
Hirsch, Joy
中科院分区：
文献类型：
--
作者：
Egner, Tobias;Etkin, Amit;Hirsch, Joy
人脑通过注意偏置机制保护任务相关刺激的处理不受任务无关刺激的干扰（“冲突”）。通过选择性地增强与任务相关的刺激在感觉皮层中的表征，前额叶外侧皮层参与解决竞争刺激之间的冲突。相反，最近的数据表明，来自情绪干扰的冲突可能通过另一种途径解决，即吻侧前扣带皮层抑制杏仁核对与任务无关的情绪刺激的反应。在这里，我们测试了两种可分离的、特定于干扰物的冲突解决机制，通过获取非情绪或情绪干扰物在解决冲突过程中的功能磁共振成像数据。结果显示了两个不同的回路：一个是解决非情绪冲突的前额叶侧“认知控制”系统，该系统与感觉皮层对任务相关刺激的强化处理有关；另一个是解决情绪冲突的吻侧前扣带“情绪控制”系统，该系统与减少杏仁核对情绪干扰物的反应有关。相比之下，在前扣带背侧的一个共同区域观察到与情绪和非情绪冲突监测相关的激活。这些数据表明，用于克服冲突的神经解剖学网络系统地随冲突的性质而变化，但它们可能共享一个共同的冲突检测机制。
The human brain protects the processing of task-relevant stimuli from interference ("conflict") by task-irrelevant stimuli via attentional biasing mechanisms. The lateral prefrontal cortex has been implicated in resolving conflict between competing stimuli by selectively enhancing task-relevant stimulus representations in sensory cortices. Conversely, recent data suggest that conflict from emotional distracters may be resolved by an alternative route, wherein the rostral anterior cingulate cortex inhibits amygdalar responsiveness to task-irrelevant emotional stimuli. Here we tested the proposal of 2 dissociable, distracter-specific conflict resolution mechanisms, by acquiring functional magnetic resonance imaging data during resolution of conflict from either nonemotional or emotional distracters. The results revealed 2 distinct circuits: a lateral prefrontal "cognitive control" system that resolved nonemotional conflict and was associated with enhanced processing of task-relevant stimuli in sensory cortices, and a rostral anterior cingulate "emotional control" system that resolved emotional conflict and was associated with decreased amygdalar responses to emotional distracters. By contrast, activations related to both emotional and nonemotional conflict monitoring were observed in a common region of the dorsal anterior cingulate. These data suggest that the neuroanatomical networks recruited to overcome conflict vary systematically with the nature of the conflict, but that they may share a common conflict-detection mechanism.